Review of anticancer mechanisms of isoquercitin

Guilherme Di Camillo Orfali, Ana Carolina Duarte, Vivien Bonadio, Natalia Peres Martinez, Maria Elisa Melo Branco De Araújo, Fernanda Priviero, Patricia Oliveira Carvalho, Denise Gonçalves Priolli

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.

Original languageEnglish (US)
Pages (from-to)189-199
Number of pages11
JournalWorld Journal of Clinical Oncology
Volume7
Issue number2
DOIs
StatePublished - Apr 10 2016
Externally publishedYes

Fingerprint

Quercetin
Biological Availability
Rutin
Flavonols
Glycosides
Flavonoids
isoquercitrin
Neoplasms
Wnt Signaling Pathway
Chemoprevention
Insurance Benefits
Mitogen-Activated Protein Kinases
PubMed
Protein Kinases
Antihypertensive Agents
Lipid Peroxidation
Publications
Anti-Inflammatory Agents
Therapeutics
Antioxidants

Keywords

  • Antioxidants
  • Antitumor
  • Cancer
  • Drug screening assays
  • Flavonoids
  • Flavonols
  • Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Di Camillo Orfali, G., Duarte, A. C., Bonadio, V., Martinez, N. P., De Araújo, M. E. M. B., Priviero, F., ... Priolli, D. G. (2016). Review of anticancer mechanisms of isoquercitin. World Journal of Clinical Oncology, 7(2), 189-199. https://doi.org/10.5306/wjco.v7.i2.189

Review of anticancer mechanisms of isoquercitin. / Di Camillo Orfali, Guilherme; Duarte, Ana Carolina; Bonadio, Vivien; Martinez, Natalia Peres; De Araújo, Maria Elisa Melo Branco; Priviero, Fernanda; Carvalho, Patricia Oliveira; Priolli, Denise Gonçalves.

In: World Journal of Clinical Oncology, Vol. 7, No. 2, 10.04.2016, p. 189-199.

Research output: Contribution to journalReview article

Di Camillo Orfali, G, Duarte, AC, Bonadio, V, Martinez, NP, De Araújo, MEMB, Priviero, F, Carvalho, PO & Priolli, DG 2016, 'Review of anticancer mechanisms of isoquercitin', World Journal of Clinical Oncology, vol. 7, no. 2, pp. 189-199. https://doi.org/10.5306/wjco.v7.i2.189
Di Camillo Orfali G, Duarte AC, Bonadio V, Martinez NP, De Araújo MEMB, Priviero F et al. Review of anticancer mechanisms of isoquercitin. World Journal of Clinical Oncology. 2016 Apr 10;7(2):189-199. https://doi.org/10.5306/wjco.v7.i2.189
Di Camillo Orfali, Guilherme ; Duarte, Ana Carolina ; Bonadio, Vivien ; Martinez, Natalia Peres ; De Araújo, Maria Elisa Melo Branco ; Priviero, Fernanda ; Carvalho, Patricia Oliveira ; Priolli, Denise Gonçalves. / Review of anticancer mechanisms of isoquercitin. In: World Journal of Clinical Oncology. 2016 ; Vol. 7, No. 2. pp. 189-199.
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