Review of anticancer mechanisms of isoquercitin

Guilherme Di Camillo Orfali, Ana Carolina Duarte, Vivien Bonadio, Natalia Peres Martinez, Maria Elisa Melo Branco De Araújo, Fernanda Priviero, Patricia Oliveira Carvalho, Denise Gonçalves Priolli

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.

Original languageEnglish (US)
Pages (from-to)189-199
Number of pages11
JournalWorld Journal of Clinical Oncology
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 10 2016
Externally publishedYes

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Keywords

  • Antioxidants
  • Antitumor
  • Cancer
  • Drug screening assays
  • Flavonoids
  • Flavonols
  • Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Di Camillo Orfali, G., Duarte, A. C., Bonadio, V., Martinez, N. P., De Araújo, M. E. M. B., Priviero, F., ... Priolli, D. G. (2016). Review of anticancer mechanisms of isoquercitin. World Journal of Clinical Oncology, 7(2), 189-199. https://doi.org/10.5306/wjco.v7.i2.189