Revisiting vitamin C in cancer therapy

Is "C" for cure, or just wishful thinking?

Fei Li, Lin Zhang, Shou Ching Tang

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

We devoted this short piece to highlight one recent article published in Science, which revisited the anti-cancer efficacy of high-dose vitamin C. Using isogeneic KRAS- and BRAF-mutated colorectal cell lines, the authors were able to demonstrate selective anti-tumor effects among the KRAS- and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin C. Their elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake, leading to lethal accumulation of reactive oxygen species (ROS). This report will certainly rekindle enthusiasm in revisiting the case of vitamin C, pushing for more definitive cancer therapy trials.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalGenes and Diseases
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2016

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Ascorbic Acid
Neoplasms
Therapeutics
Tumors
Reactive Oxygen Species
Animals
Animal Models
Cell Culture Techniques
Cells
Cell Line

Keywords

  • BRAF
  • Cancer
  • Chemotherapy
  • KRAS
  • Vitamin C

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Genetics(clinical)

Cite this

Revisiting vitamin C in cancer therapy : Is "C" for cure, or just wishful thinking? / Li, Fei; Zhang, Lin; Tang, Shou Ching.

In: Genes and Diseases, Vol. 3, No. 1, 01.03.2016, p. 1-2.

Research output: Contribution to journalComment/debate

Li, Fei ; Zhang, Lin ; Tang, Shou Ching. / Revisiting vitamin C in cancer therapy : Is "C" for cure, or just wishful thinking?. In: Genes and Diseases. 2016 ; Vol. 3, No. 1. pp. 1-2.
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