Rifampin prophylaxis for contacts of Haemophilus influenzae type b disease

F. Cox, R. Trincher, J. P. Rissing, M. Patton, G. H. McCracken, D. M. Granoff

Research output: Contribution to journalArticle

Abstract

Rifampin prophylaxis (20 mg/kg once daily for four days) was used in close contacts of children with Haemophilus influenzae type b (HIB) disease. Two hours after a dose, the concentration of rifampin in serum and saliva exceeded the minimum bactericidal concentrations of organisms obtained from four of the carriers. In both a randomized prospective and an open study, nasopharyngeal carriage was eradicated in 37 (95%) of 39 contacts. No cases of serious H influenzae disease occurred in four to six months of follow-up. At the dose and treatment schedule used, rifampin was safe and effective for eradication of HIB carriage.

Original languageEnglish (US)
Pages (from-to)1043-1045
Number of pages3
JournalJournal of the American Medical Association
Volume245
Issue number10
DOIs
StatePublished - May 8 1981

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Haemophilus influenzae type b
Rifampin
Saliva
Human Influenza
Appointments and Schedules
Prospective Studies
Serum
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Rifampin prophylaxis for contacts of Haemophilus influenzae type b disease. / Cox, F.; Trincher, R.; Rissing, J. P.; Patton, M.; McCracken, G. H.; Granoff, D. M.

In: Journal of the American Medical Association, Vol. 245, No. 10, 08.05.1981, p. 1043-1045.

Research output: Contribution to journalArticle

Cox, F. ; Trincher, R. ; Rissing, J. P. ; Patton, M. ; McCracken, G. H. ; Granoff, D. M. / Rifampin prophylaxis for contacts of Haemophilus influenzae type b disease. In: Journal of the American Medical Association. 1981 ; Vol. 245, No. 10. pp. 1043-1045.
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