Risk assessment of a cohort exposed to aromatic amines

Initial results

Paul A. Schulte, Knut Ringen, George P. Hemstreet, Ernest B. Altekruse, Warren H. Gullen, Maurice G. Patton, William C. Allsbrook, John H Crosby, Seymour S. West, Roy Witherington, Leopold Koss, Carol E. Bales, Sandra Tillet, Shirley C.F. Rooks, Frank Stern, William Stringer, Verleen A. Schmidt, Margaret M. Brubaker

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A cohort of 1,385 workers potentially exposed to carcinogenic amines was evaluated to determine the extent of its risk for bladder cancer. The cumulative incidence of bladder cancer was determined from death certificates, from interviews with community urologists, and from a screening program. A total of 13 confirmed cases of bladder cancer were identified at the conclusion of the first year of study. The entire cohort has approximately a fourfold excess risk of bladder cancer; however, black workers with more than 10 years of employment had a risk ratio of 111 (based on three cases). The onset of disease occurred, on the average, 15 years earlier in these black workers than in the general U.S. population. The cumulative incidence of bladder cancer increased with the duration of employment, ranging from 0.4% for workers with five or fewer years of employment to 36% for those with greater than 20 years. No significant differences were found between cases and noncases for cigarette smoking, coffee drinking, use of artificial sweeteners, or prior employment in highrisk occupations. More cases of bladder cancer are expected in this cohort because many members have not yet achieved the average latency found for the confirmed cases.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalJournal of Occupational Medicine
Volume27
Issue number2
StatePublished - Jan 1 1985

Fingerprint

Urinary Bladder Neoplasms
Amines
Sweetening Agents
Death Certificates
Coffee
Incidence
Occupations
Drinking
Smoking
Odds Ratio
Interviews
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Schulte, P. A., Ringen, K., Hemstreet, G. P., Altekruse, E. B., Gullen, W. H., Patton, M. G., ... Brubaker, M. M. (1985). Risk assessment of a cohort exposed to aromatic amines: Initial results. Journal of Occupational Medicine, 27(2), 115-121.

Risk assessment of a cohort exposed to aromatic amines : Initial results. / Schulte, Paul A.; Ringen, Knut; Hemstreet, George P.; Altekruse, Ernest B.; Gullen, Warren H.; Patton, Maurice G.; Allsbrook, William C.; Crosby, John H; West, Seymour S.; Witherington, Roy; Koss, Leopold; Bales, Carol E.; Tillet, Sandra; Rooks, Shirley C.F.; Stern, Frank; Stringer, William; Schmidt, Verleen A.; Brubaker, Margaret M.

In: Journal of Occupational Medicine, Vol. 27, No. 2, 01.01.1985, p. 115-121.

Research output: Contribution to journalArticle

Schulte, PA, Ringen, K, Hemstreet, GP, Altekruse, EB, Gullen, WH, Patton, MG, Allsbrook, WC, Crosby, JH, West, SS, Witherington, R, Koss, L, Bales, CE, Tillet, S, Rooks, SCF, Stern, F, Stringer, W, Schmidt, VA & Brubaker, MM 1985, 'Risk assessment of a cohort exposed to aromatic amines: Initial results', Journal of Occupational Medicine, vol. 27, no. 2, pp. 115-121.
Schulte PA, Ringen K, Hemstreet GP, Altekruse EB, Gullen WH, Patton MG et al. Risk assessment of a cohort exposed to aromatic amines: Initial results. Journal of Occupational Medicine. 1985 Jan 1;27(2):115-121.
Schulte, Paul A. ; Ringen, Knut ; Hemstreet, George P. ; Altekruse, Ernest B. ; Gullen, Warren H. ; Patton, Maurice G. ; Allsbrook, William C. ; Crosby, John H ; West, Seymour S. ; Witherington, Roy ; Koss, Leopold ; Bales, Carol E. ; Tillet, Sandra ; Rooks, Shirley C.F. ; Stern, Frank ; Stringer, William ; Schmidt, Verleen A. ; Brubaker, Margaret M. / Risk assessment of a cohort exposed to aromatic amines : Initial results. In: Journal of Occupational Medicine. 1985 ; Vol. 27, No. 2. pp. 115-121.
@article{f32be430c9eb4ad9a33dc7b097b5ece8,
title = "Risk assessment of a cohort exposed to aromatic amines: Initial results",
abstract = "A cohort of 1,385 workers potentially exposed to carcinogenic amines was evaluated to determine the extent of its risk for bladder cancer. The cumulative incidence of bladder cancer was determined from death certificates, from interviews with community urologists, and from a screening program. A total of 13 confirmed cases of bladder cancer were identified at the conclusion of the first year of study. The entire cohort has approximately a fourfold excess risk of bladder cancer; however, black workers with more than 10 years of employment had a risk ratio of 111 (based on three cases). The onset of disease occurred, on the average, 15 years earlier in these black workers than in the general U.S. population. The cumulative incidence of bladder cancer increased with the duration of employment, ranging from 0.4{\%} for workers with five or fewer years of employment to 36{\%} for those with greater than 20 years. No significant differences were found between cases and noncases for cigarette smoking, coffee drinking, use of artificial sweeteners, or prior employment in highrisk occupations. More cases of bladder cancer are expected in this cohort because many members have not yet achieved the average latency found for the confirmed cases.",
author = "Schulte, {Paul A.} and Knut Ringen and Hemstreet, {George P.} and Altekruse, {Ernest B.} and Gullen, {Warren H.} and Patton, {Maurice G.} and Allsbrook, {William C.} and Crosby, {John H} and West, {Seymour S.} and Roy Witherington and Leopold Koss and Bales, {Carol E.} and Sandra Tillet and Rooks, {Shirley C.F.} and Frank Stern and William Stringer and Schmidt, {Verleen A.} and Brubaker, {Margaret M.}",
year = "1985",
month = "1",
day = "1",
language = "English (US)",
volume = "27",
pages = "115--121",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Risk assessment of a cohort exposed to aromatic amines

T2 - Initial results

AU - Schulte, Paul A.

AU - Ringen, Knut

AU - Hemstreet, George P.

AU - Altekruse, Ernest B.

AU - Gullen, Warren H.

AU - Patton, Maurice G.

AU - Allsbrook, William C.

AU - Crosby, John H

AU - West, Seymour S.

AU - Witherington, Roy

AU - Koss, Leopold

AU - Bales, Carol E.

AU - Tillet, Sandra

AU - Rooks, Shirley C.F.

AU - Stern, Frank

AU - Stringer, William

AU - Schmidt, Verleen A.

AU - Brubaker, Margaret M.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - A cohort of 1,385 workers potentially exposed to carcinogenic amines was evaluated to determine the extent of its risk for bladder cancer. The cumulative incidence of bladder cancer was determined from death certificates, from interviews with community urologists, and from a screening program. A total of 13 confirmed cases of bladder cancer were identified at the conclusion of the first year of study. The entire cohort has approximately a fourfold excess risk of bladder cancer; however, black workers with more than 10 years of employment had a risk ratio of 111 (based on three cases). The onset of disease occurred, on the average, 15 years earlier in these black workers than in the general U.S. population. The cumulative incidence of bladder cancer increased with the duration of employment, ranging from 0.4% for workers with five or fewer years of employment to 36% for those with greater than 20 years. No significant differences were found between cases and noncases for cigarette smoking, coffee drinking, use of artificial sweeteners, or prior employment in highrisk occupations. More cases of bladder cancer are expected in this cohort because many members have not yet achieved the average latency found for the confirmed cases.

AB - A cohort of 1,385 workers potentially exposed to carcinogenic amines was evaluated to determine the extent of its risk for bladder cancer. The cumulative incidence of bladder cancer was determined from death certificates, from interviews with community urologists, and from a screening program. A total of 13 confirmed cases of bladder cancer were identified at the conclusion of the first year of study. The entire cohort has approximately a fourfold excess risk of bladder cancer; however, black workers with more than 10 years of employment had a risk ratio of 111 (based on three cases). The onset of disease occurred, on the average, 15 years earlier in these black workers than in the general U.S. population. The cumulative incidence of bladder cancer increased with the duration of employment, ranging from 0.4% for workers with five or fewer years of employment to 36% for those with greater than 20 years. No significant differences were found between cases and noncases for cigarette smoking, coffee drinking, use of artificial sweeteners, or prior employment in highrisk occupations. More cases of bladder cancer are expected in this cohort because many members have not yet achieved the average latency found for the confirmed cases.

UR - http://www.scopus.com/inward/record.url?scp=0021988645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021988645&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 115

EP - 121

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 2

ER -