Risk Factors

Diabetes

Adviye Ergul, S. C. Fagan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Increased mortality and morbidity associated with diabetes arises from its complications, all of which have a prominent vascular component. Cerebral complications of diabetes including stroke and cognitive impairment are the least studied complications of the disease. Diabetes not only increases the risk but also worsens the progression and outcome of these diseases. Although underlying reasons are multifactorial, experimental models have revealed that diabetes mediates pathological changes in the cerebrovascular structure and function that may explain some of the clinical observations. Early vascular dysfunction initiates a perpetual cascade of cerebral perfusion abnormalities leading to pathological remodeling and neovascularization of the cerebrovasculature as well as development of neuronal dysfunction. Collectively, these changes contribute to development of cognitive impairment and occurrence of stroke, which worsens cognitive and motor deficits. Thus early interventions to improve cerebrovascular function have the potential to limit the devastating cerebral complications of diabetes.

Original languageEnglish (US)
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages158-162
Number of pages5
ISBN (Print)9780128030585
DOIs
StatePublished - Mar 7 2017

Fingerprint

Diabetes Complications
Blood Vessels
Stroke
Pathologic Neovascularization
Disease Progression
Theoretical Models
Perfusion
Morbidity
Mortality
Cognitive Dysfunction

Keywords

  • Barrier function
  • Cerebral vasculature
  • Cognitive impairment
  • Diabetes
  • Neovascularization
  • Pericyte
  • Stroke
  • Vascular function
  • Vascular structure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ergul, A., & Fagan, S. C. (2017). Risk Factors: Diabetes. In Primer on Cerebrovascular Diseases: Second Edition (pp. 158-162). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803058-5.00032-1

Risk Factors : Diabetes. / Ergul, Adviye; Fagan, S. C.

Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., 2017. p. 158-162.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ergul, A & Fagan, SC 2017, Risk Factors: Diabetes. in Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., pp. 158-162. https://doi.org/10.1016/B978-0-12-803058-5.00032-1
Ergul A, Fagan SC. Risk Factors: Diabetes. In Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc. 2017. p. 158-162 https://doi.org/10.1016/B978-0-12-803058-5.00032-1
Ergul, Adviye ; Fagan, S. C. / Risk Factors : Diabetes. Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., 2017. pp. 158-162
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