Risk factors for bladder cancer in a cohort exposed to aromatic amines

Paul A. Schulte, Knut Ringen, George P. Hemstreet, Ernest B. Altekruse, Warren H. Gullen, Sandra Tillett, William C. Allsbrook, John H Crosby, Roy Witherington, William Stringer, Margaret M. Brubaker

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Occupational and nonoccupational risk factors for bladder cancer were analyzed in a cohort of 1385 workers with known exposure to a potent bladder carcinogen, beta‐naphthylamine. Bladder cancer was approximately seven times (95% confidence interval [CI] = 3.9, 12.4) more likely in exposed rather than nonexposed individuals, yet, otherwise, the groups were generally similar in other exogenous or hereditary risk factors. A total of 13 cases of bladder cancer were identified. After the first year of a screening program involving 380 members of the cohort, 9 of the 13 cases of bladder cancer and 36 persons with atypical bladder cytology, histology, or pathology were compared with 335 noncases for distributions of different variables. Occupational variables were significant in a multivariate model that controlled for age, cigarette smoking history, and source of drinking water. The estimated odds ratio for the association for bladder cancer and the duration of employment, when controlling of these other variables, is 4.3 (95% CI = 1.8, 10.3). In addition to the occupational factors, age was significant in the multivariate analysis. Other potential risk factors, such as consumption of coffee or artificial sweeteners, use of phenacetin, or decreased use of vitamin A were not found to be significantly different in cases and noncases.

Original languageEnglish (US)
Pages (from-to)2156-2162
Number of pages7
JournalCancer
Volume58
Issue number9
DOIs
StatePublished - Jan 1 1986

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Urinary Bladder Neoplasms
Amines
Urinary Bladder
Confidence Intervals
Phenacetin
Sweetening Agents
Age Factors
Coffee
Vitamin A
Drinking Water
Carcinogens
Cell Biology
Histology
Multivariate Analysis
Smoking
History
Odds Ratio
Pathology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Schulte, P. A., Ringen, K., Hemstreet, G. P., Altekruse, E. B., Gullen, W. H., Tillett, S., ... Brubaker, M. M. (1986). Risk factors for bladder cancer in a cohort exposed to aromatic amines. Cancer, 58(9), 2156-2162. https://doi.org/10.1002/1097-0142(19861101)58:9<2156::AID-CNCR2820580933>3.0.CO;2-Y

Risk factors for bladder cancer in a cohort exposed to aromatic amines. / Schulte, Paul A.; Ringen, Knut; Hemstreet, George P.; Altekruse, Ernest B.; Gullen, Warren H.; Tillett, Sandra; Allsbrook, William C.; Crosby, John H; Witherington, Roy; Stringer, William; Brubaker, Margaret M.

In: Cancer, Vol. 58, No. 9, 01.01.1986, p. 2156-2162.

Research output: Contribution to journalArticle

Schulte, PA, Ringen, K, Hemstreet, GP, Altekruse, EB, Gullen, WH, Tillett, S, Allsbrook, WC, Crosby, JH, Witherington, R, Stringer, W & Brubaker, MM 1986, 'Risk factors for bladder cancer in a cohort exposed to aromatic amines', Cancer, vol. 58, no. 9, pp. 2156-2162. https://doi.org/10.1002/1097-0142(19861101)58:9<2156::AID-CNCR2820580933>3.0.CO;2-Y
Schulte PA, Ringen K, Hemstreet GP, Altekruse EB, Gullen WH, Tillett S et al. Risk factors for bladder cancer in a cohort exposed to aromatic amines. Cancer. 1986 Jan 1;58(9):2156-2162. https://doi.org/10.1002/1097-0142(19861101)58:9<2156::AID-CNCR2820580933>3.0.CO;2-Y
Schulte, Paul A. ; Ringen, Knut ; Hemstreet, George P. ; Altekruse, Ernest B. ; Gullen, Warren H. ; Tillett, Sandra ; Allsbrook, William C. ; Crosby, John H ; Witherington, Roy ; Stringer, William ; Brubaker, Margaret M. / Risk factors for bladder cancer in a cohort exposed to aromatic amines. In: Cancer. 1986 ; Vol. 58, No. 9. pp. 2156-2162.
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