Risk factors for intracerebral hemorrhage

The reasons for geographic and racial differences in stroke (REGARDS) study

George Howard, Mary Cushman, Virginia J. Howard, Brett M. Kissela, Dawn O. Kleindorfer, Claudia S. Moy, Jeffrey A Switzer, Daniel Woo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-: Risk factors for intracerebral hemorrhage (ICH) have been largely identified in case-control studies, with few longitudinal studies available. METHODS-: Predictors of incident ICH among 27 760 black and white participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study were assessed. RESULTS-: There were 62 incident ICH events during an average follow-up of 5.7 years. The increase in risk with age differed substantially between blacks and whites (P=0.006), with a 2.25-fold (95% confidence interval, 1.63-3.12) increase per decade in whites, but no age association with ICH risk in blacks (hazard ratio=1.09; 95% confidence interval, 0.70-1.68). We observed increased risk among men, those with higher systolic blood pressure, and warfarin users. CONCLUSIONS-: The racial differences in the impact of age contributed to a risk of ICH that was >5 times higher for blacks than whites at age 45, but only about one third as great by age 85. Confirming findings from other studies, men participants with elevated systolic blood pressure and warfarin users were also at greater risk. The contributors to the racial differences in ICH risk require additional investigation.

Original languageEnglish (US)
Pages (from-to)1282-1287
Number of pages6
JournalStroke
Volume44
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Cerebral Hemorrhage
Stroke
Warfarin
Blood Pressure
Confidence Intervals
Longitudinal Studies
Case-Control Studies
Cohort Studies
Hypertension
hydroquinone

Keywords

  • black race
  • hypertension
  • intracerebral hemorrhage
  • risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Howard, G., Cushman, M., Howard, V. J., Kissela, B. M., Kleindorfer, D. O., Moy, C. S., ... Woo, D. (2013). Risk factors for intracerebral hemorrhage: The reasons for geographic and racial differences in stroke (REGARDS) study. Stroke, 44(5), 1282-1287. https://doi.org/10.1161/STROKEAHA.111.000529

Risk factors for intracerebral hemorrhage : The reasons for geographic and racial differences in stroke (REGARDS) study. / Howard, George; Cushman, Mary; Howard, Virginia J.; Kissela, Brett M.; Kleindorfer, Dawn O.; Moy, Claudia S.; Switzer, Jeffrey A; Woo, Daniel.

In: Stroke, Vol. 44, No. 5, 01.05.2013, p. 1282-1287.

Research output: Contribution to journalArticle

Howard, G, Cushman, M, Howard, VJ, Kissela, BM, Kleindorfer, DO, Moy, CS, Switzer, JA & Woo, D 2013, 'Risk factors for intracerebral hemorrhage: The reasons for geographic and racial differences in stroke (REGARDS) study', Stroke, vol. 44, no. 5, pp. 1282-1287. https://doi.org/10.1161/STROKEAHA.111.000529
Howard, George ; Cushman, Mary ; Howard, Virginia J. ; Kissela, Brett M. ; Kleindorfer, Dawn O. ; Moy, Claudia S. ; Switzer, Jeffrey A ; Woo, Daniel. / Risk factors for intracerebral hemorrhage : The reasons for geographic and racial differences in stroke (REGARDS) study. In: Stroke. 2013 ; Vol. 44, No. 5. pp. 1282-1287.
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