Abstract
Aprotinin has been shown to reduce transfusion requirements in re-operative cardiac surgery and in implantation of long-term left ventricular assist devices (LVAD). However, it is an antigenic polypeptide and re-exposure is associated with a small incidence of anaphylaxis. This report describes 2 cases of anaphylactic response to aprotinin when the agent was employed for both the LVAD implant and for the subsequent explant and cardiac transplant. Early re-exposure to just the test dose was associated with a significant incidence of anaphylaxis.
Original language | English (US) |
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Pages (from-to) | 1127-1130 |
Number of pages | 4 |
Journal | Journal of Heart and Lung Transplantation |
Volume | 21 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine
- Transplantation