Risk Stratification for Biochemical Recurrence in Men With Positive Surgical Margins or Extracapsular Disease After Radical Prostatectomy: Results From the SEARCH Database

Jayakrishnan Jayachandran, Lionel L. Bañez, Donna E. Levy, William J. Aronson, Martha Kennedy Terris, Joseph C. Presti, Christopher L. Amling, Christopher J. Kane, Stephen J. Freedland

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: In men with extracapsular disease or positive surgical margins after radical prostatectomy immediate adjuvant therapy decreases the risk of biochemical recurrence at the cost of increased toxicity. We further stratified these men into a low risk group in which watchful waiting after surgery may be preferred and a high risk cohort in which adjuvant therapy may be preferred. Materials and Methods: We performed a retrospective analysis of the records of 902 men treated with radical prostatectomy in the Shared Equal-Access Regional Cancer Hospital (SEARCH) database between 1988 and 2007 with positive surgical margins and/or extracapsular disease without seminal vesicle invasion or lymph node metastasis. The significant independent predictors of biochemical recurrence were determined using a multivariate Cox proportional hazards model. Based on the recurrence risk generated from the multivariate Cox proportional hazards regression model we generated tables to estimate the risk of recurrence-free survival 1, 3 and 5 years after surgery. Results: At a median of 3 years of followup 346 patients (39%) had biochemical recurrence. On multivariate analysis the significant predictors of biochemical recurrence were age more than 60 years, prostate specific antigen more than 10 ng/ml, Gleason score 4 + 3 and 8-10, 2 or more sites of positive surgical margins and prostate specimen weight 30 gm or less. As determined by the concordance index, the overall predictive accuracy of the model was 0.67, while it was 0.60 for the postoperative Kattan nomogram in this patient population. Conclusions: We have developed a simple instrument that, once validated, may aid in the postoperative decision making process for men at intermediate risk for recurrence after prostatectomy.

Original languageEnglish (US)
Pages (from-to)1791-1796
Number of pages6
JournalJournal of Urology
Volume179
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Cancer Care Facilities
Prostatectomy
Databases
Recurrence
Proportional Hazards Models
Watchful Waiting
Nomograms
Neoplasm Grading
Seminal Vesicles
Prostate-Specific Antigen
Margins of Excision
Prostate
Decision Making
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Weights and Measures
Survival
Therapeutics
Population

Keywords

  • prostate
  • prostate-specific antigen
  • prostatectomy
  • prostatic neoplasms
  • risk

ASJC Scopus subject areas

  • Urology

Cite this

Risk Stratification for Biochemical Recurrence in Men With Positive Surgical Margins or Extracapsular Disease After Radical Prostatectomy : Results From the SEARCH Database. / Jayachandran, Jayakrishnan; Bañez, Lionel L.; Levy, Donna E.; Aronson, William J.; Terris, Martha Kennedy; Presti, Joseph C.; Amling, Christopher L.; Kane, Christopher J.; Freedland, Stephen J.

In: Journal of Urology, Vol. 179, No. 5, 01.05.2008, p. 1791-1796.

Research output: Contribution to journalArticle

Jayachandran, Jayakrishnan ; Bañez, Lionel L. ; Levy, Donna E. ; Aronson, William J. ; Terris, Martha Kennedy ; Presti, Joseph C. ; Amling, Christopher L. ; Kane, Christopher J. ; Freedland, Stephen J. / Risk Stratification for Biochemical Recurrence in Men With Positive Surgical Margins or Extracapsular Disease After Radical Prostatectomy : Results From the SEARCH Database. In: Journal of Urology. 2008 ; Vol. 179, No. 5. pp. 1791-1796.
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abstract = "Purpose: In men with extracapsular disease or positive surgical margins after radical prostatectomy immediate adjuvant therapy decreases the risk of biochemical recurrence at the cost of increased toxicity. We further stratified these men into a low risk group in which watchful waiting after surgery may be preferred and a high risk cohort in which adjuvant therapy may be preferred. Materials and Methods: We performed a retrospective analysis of the records of 902 men treated with radical prostatectomy in the Shared Equal-Access Regional Cancer Hospital (SEARCH) database between 1988 and 2007 with positive surgical margins and/or extracapsular disease without seminal vesicle invasion or lymph node metastasis. The significant independent predictors of biochemical recurrence were determined using a multivariate Cox proportional hazards model. Based on the recurrence risk generated from the multivariate Cox proportional hazards regression model we generated tables to estimate the risk of recurrence-free survival 1, 3 and 5 years after surgery. Results: At a median of 3 years of followup 346 patients (39{\%}) had biochemical recurrence. On multivariate analysis the significant predictors of biochemical recurrence were age more than 60 years, prostate specific antigen more than 10 ng/ml, Gleason score 4 + 3 and 8-10, 2 or more sites of positive surgical margins and prostate specimen weight 30 gm or less. As determined by the concordance index, the overall predictive accuracy of the model was 0.67, while it was 0.60 for the postoperative Kattan nomogram in this patient population. Conclusions: We have developed a simple instrument that, once validated, may aid in the postoperative decision making process for men at intermediate risk for recurrence after prostatectomy.",
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AU - Bañez, Lionel L.

AU - Levy, Donna E.

AU - Aronson, William J.

AU - Terris, Martha Kennedy

AU - Presti, Joseph C.

AU - Amling, Christopher L.

AU - Kane, Christopher J.

AU - Freedland, Stephen J.

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AB - Purpose: In men with extracapsular disease or positive surgical margins after radical prostatectomy immediate adjuvant therapy decreases the risk of biochemical recurrence at the cost of increased toxicity. We further stratified these men into a low risk group in which watchful waiting after surgery may be preferred and a high risk cohort in which adjuvant therapy may be preferred. Materials and Methods: We performed a retrospective analysis of the records of 902 men treated with radical prostatectomy in the Shared Equal-Access Regional Cancer Hospital (SEARCH) database between 1988 and 2007 with positive surgical margins and/or extracapsular disease without seminal vesicle invasion or lymph node metastasis. The significant independent predictors of biochemical recurrence were determined using a multivariate Cox proportional hazards model. Based on the recurrence risk generated from the multivariate Cox proportional hazards regression model we generated tables to estimate the risk of recurrence-free survival 1, 3 and 5 years after surgery. Results: At a median of 3 years of followup 346 patients (39%) had biochemical recurrence. On multivariate analysis the significant predictors of biochemical recurrence were age more than 60 years, prostate specific antigen more than 10 ng/ml, Gleason score 4 + 3 and 8-10, 2 or more sites of positive surgical margins and prostate specimen weight 30 gm or less. As determined by the concordance index, the overall predictive accuracy of the model was 0.67, while it was 0.60 for the postoperative Kattan nomogram in this patient population. Conclusions: We have developed a simple instrument that, once validated, may aid in the postoperative decision making process for men at intermediate risk for recurrence after prostatectomy.

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