Robotically guided radiosurgery for children

Cole A. Giller, Brian D. Berger, David A. Pistenmaa, Frederick Sklar, Bradley Weprin, Kenneth Shapiro, Naomi Winick, Arlynn F. Mulne, Janice L. Delp, Joseph P. Gilio, Kenneth P. Gall, Karel A. Dicke, Dale Swift, David Sacco, Kesha Harris-Henderson, Daniel Bowers

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background. A robotically guided linear accelerator has recently been developed which provides frameless radiosurgery with high precision. Potential advantages for the pediatric population include the avoidance of the cognitive decline associated with whole brain radiotherapy, the ability to treat young children with thin skulls unsuitable for frame-based methods, and the possible avoidance of general anesthesia. We report our experience with this system (the "Cyberknife") in the treatment of 21 children. Procedures. Cyberknife radiosurgery was performed on 38 occasions for 21 patients, age ranging from 8 months to 16 years (7.0 ± 5.1 years), with tumors considered unresectable. Three had pilocytic astrocytomas, two had anaplastic astrocytomas, three had ependymomas (two anaplastic), four had medulloblastomas, three had atypical teratoid/ rhabdoid tumors, three had craniopharyngiomas, and three had other pathologies. The mean target volume was 10.7 ± 20 cm3, mean marginal dose was 18.8 ± 8.1 Gy, and mean follow-up is 18 ± 11 months. Twenty-seven (71%) of the treatments were single-shot and eight (38%) patients did not require general anesthesia. Results. Local control was achieved in the patients with pilocytic and anaplastic astrocytoma, three of the patients with medulloblastoma, and the three with craniopharyngioma, but not for those with ependymoma. Two of the patients with rhabdoid tumors are alive 16 and 35 months after this diagnosis. There have been no procedure related deaths or complications. Conclusion. Cyberknife radiosurgery can be used to achieve local control for some children with CNS tumors without the need for rigid head fixation.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalPediatric Blood and Cancer
Volume45
Issue number3
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

Fingerprint

Radiosurgery
Astrocytoma
Craniopharyngioma
Ependymoma
Medulloblastoma
General Anesthesia
Rhabdoid Tumor
Particle Accelerators
Aptitude
Skull
Neoplasms
Radiotherapy
Head
Pediatrics
Pathology
Brain
Therapeutics
Population

Keywords

  • Cyberknife
  • Pediatric brain tumors
  • Radiosurgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Giller, C. A., Berger, B. D., Pistenmaa, D. A., Sklar, F., Weprin, B., Shapiro, K., ... Bowers, D. (2005). Robotically guided radiosurgery for children. Pediatric Blood and Cancer, 45(3), 304-310. https://doi.org/10.1002/pbc.20267

Robotically guided radiosurgery for children. / Giller, Cole A.; Berger, Brian D.; Pistenmaa, David A.; Sklar, Frederick; Weprin, Bradley; Shapiro, Kenneth; Winick, Naomi; Mulne, Arlynn F.; Delp, Janice L.; Gilio, Joseph P.; Gall, Kenneth P.; Dicke, Karel A.; Swift, Dale; Sacco, David; Harris-Henderson, Kesha; Bowers, Daniel.

In: Pediatric Blood and Cancer, Vol. 45, No. 3, 01.09.2005, p. 304-310.

Research output: Contribution to journalArticle

Giller, CA, Berger, BD, Pistenmaa, DA, Sklar, F, Weprin, B, Shapiro, K, Winick, N, Mulne, AF, Delp, JL, Gilio, JP, Gall, KP, Dicke, KA, Swift, D, Sacco, D, Harris-Henderson, K & Bowers, D 2005, 'Robotically guided radiosurgery for children', Pediatric Blood and Cancer, vol. 45, no. 3, pp. 304-310. https://doi.org/10.1002/pbc.20267
Giller CA, Berger BD, Pistenmaa DA, Sklar F, Weprin B, Shapiro K et al. Robotically guided radiosurgery for children. Pediatric Blood and Cancer. 2005 Sep 1;45(3):304-310. https://doi.org/10.1002/pbc.20267
Giller, Cole A. ; Berger, Brian D. ; Pistenmaa, David A. ; Sklar, Frederick ; Weprin, Bradley ; Shapiro, Kenneth ; Winick, Naomi ; Mulne, Arlynn F. ; Delp, Janice L. ; Gilio, Joseph P. ; Gall, Kenneth P. ; Dicke, Karel A. ; Swift, Dale ; Sacco, David ; Harris-Henderson, Kesha ; Bowers, Daniel. / Robotically guided radiosurgery for children. In: Pediatric Blood and Cancer. 2005 ; Vol. 45, No. 3. pp. 304-310.
@article{3b87c47def2943e49ba18fc5ba8aafc2,
title = "Robotically guided radiosurgery for children",
abstract = "Background. A robotically guided linear accelerator has recently been developed which provides frameless radiosurgery with high precision. Potential advantages for the pediatric population include the avoidance of the cognitive decline associated with whole brain radiotherapy, the ability to treat young children with thin skulls unsuitable for frame-based methods, and the possible avoidance of general anesthesia. We report our experience with this system (the {"}Cyberknife{"}) in the treatment of 21 children. Procedures. Cyberknife radiosurgery was performed on 38 occasions for 21 patients, age ranging from 8 months to 16 years (7.0 ± 5.1 years), with tumors considered unresectable. Three had pilocytic astrocytomas, two had anaplastic astrocytomas, three had ependymomas (two anaplastic), four had medulloblastomas, three had atypical teratoid/ rhabdoid tumors, three had craniopharyngiomas, and three had other pathologies. The mean target volume was 10.7 ± 20 cm3, mean marginal dose was 18.8 ± 8.1 Gy, and mean follow-up is 18 ± 11 months. Twenty-seven (71{\%}) of the treatments were single-shot and eight (38{\%}) patients did not require general anesthesia. Results. Local control was achieved in the patients with pilocytic and anaplastic astrocytoma, three of the patients with medulloblastoma, and the three with craniopharyngioma, but not for those with ependymoma. Two of the patients with rhabdoid tumors are alive 16 and 35 months after this diagnosis. There have been no procedure related deaths or complications. Conclusion. Cyberknife radiosurgery can be used to achieve local control for some children with CNS tumors without the need for rigid head fixation.",
keywords = "Cyberknife, Pediatric brain tumors, Radiosurgery",
author = "Giller, {Cole A.} and Berger, {Brian D.} and Pistenmaa, {David A.} and Frederick Sklar and Bradley Weprin and Kenneth Shapiro and Naomi Winick and Mulne, {Arlynn F.} and Delp, {Janice L.} and Gilio, {Joseph P.} and Gall, {Kenneth P.} and Dicke, {Karel A.} and Dale Swift and David Sacco and Kesha Harris-Henderson and Daniel Bowers",
year = "2005",
month = "9",
day = "1",
doi = "10.1002/pbc.20267",
language = "English (US)",
volume = "45",
pages = "304--310",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Robotically guided radiosurgery for children

AU - Giller, Cole A.

AU - Berger, Brian D.

AU - Pistenmaa, David A.

AU - Sklar, Frederick

AU - Weprin, Bradley

AU - Shapiro, Kenneth

AU - Winick, Naomi

AU - Mulne, Arlynn F.

AU - Delp, Janice L.

AU - Gilio, Joseph P.

AU - Gall, Kenneth P.

AU - Dicke, Karel A.

AU - Swift, Dale

AU - Sacco, David

AU - Harris-Henderson, Kesha

AU - Bowers, Daniel

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Background. A robotically guided linear accelerator has recently been developed which provides frameless radiosurgery with high precision. Potential advantages for the pediatric population include the avoidance of the cognitive decline associated with whole brain radiotherapy, the ability to treat young children with thin skulls unsuitable for frame-based methods, and the possible avoidance of general anesthesia. We report our experience with this system (the "Cyberknife") in the treatment of 21 children. Procedures. Cyberknife radiosurgery was performed on 38 occasions for 21 patients, age ranging from 8 months to 16 years (7.0 ± 5.1 years), with tumors considered unresectable. Three had pilocytic astrocytomas, two had anaplastic astrocytomas, three had ependymomas (two anaplastic), four had medulloblastomas, three had atypical teratoid/ rhabdoid tumors, three had craniopharyngiomas, and three had other pathologies. The mean target volume was 10.7 ± 20 cm3, mean marginal dose was 18.8 ± 8.1 Gy, and mean follow-up is 18 ± 11 months. Twenty-seven (71%) of the treatments were single-shot and eight (38%) patients did not require general anesthesia. Results. Local control was achieved in the patients with pilocytic and anaplastic astrocytoma, three of the patients with medulloblastoma, and the three with craniopharyngioma, but not for those with ependymoma. Two of the patients with rhabdoid tumors are alive 16 and 35 months after this diagnosis. There have been no procedure related deaths or complications. Conclusion. Cyberknife radiosurgery can be used to achieve local control for some children with CNS tumors without the need for rigid head fixation.

AB - Background. A robotically guided linear accelerator has recently been developed which provides frameless radiosurgery with high precision. Potential advantages for the pediatric population include the avoidance of the cognitive decline associated with whole brain radiotherapy, the ability to treat young children with thin skulls unsuitable for frame-based methods, and the possible avoidance of general anesthesia. We report our experience with this system (the "Cyberknife") in the treatment of 21 children. Procedures. Cyberknife radiosurgery was performed on 38 occasions for 21 patients, age ranging from 8 months to 16 years (7.0 ± 5.1 years), with tumors considered unresectable. Three had pilocytic astrocytomas, two had anaplastic astrocytomas, three had ependymomas (two anaplastic), four had medulloblastomas, three had atypical teratoid/ rhabdoid tumors, three had craniopharyngiomas, and three had other pathologies. The mean target volume was 10.7 ± 20 cm3, mean marginal dose was 18.8 ± 8.1 Gy, and mean follow-up is 18 ± 11 months. Twenty-seven (71%) of the treatments were single-shot and eight (38%) patients did not require general anesthesia. Results. Local control was achieved in the patients with pilocytic and anaplastic astrocytoma, three of the patients with medulloblastoma, and the three with craniopharyngioma, but not for those with ependymoma. Two of the patients with rhabdoid tumors are alive 16 and 35 months after this diagnosis. There have been no procedure related deaths or complications. Conclusion. Cyberknife radiosurgery can be used to achieve local control for some children with CNS tumors without the need for rigid head fixation.

KW - Cyberknife

KW - Pediatric brain tumors

KW - Radiosurgery

UR - http://www.scopus.com/inward/record.url?scp=23044492551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23044492551&partnerID=8YFLogxK

U2 - 10.1002/pbc.20267

DO - 10.1002/pbc.20267

M3 - Article

VL - 45

SP - 304

EP - 310

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 3

ER -