Abstract
Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of Β-catenin in acute kidney injury. Although Β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, Β-catenin suppresses wound healing. Moreover, continuous activation of Β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by Β-catenin and related signaling in kidney injury, repair, and fibrosis.
Original language | English (US) |
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Pages (from-to) | 509-511 |
Number of pages | 3 |
Journal | Kidney International |
Volume | 82 |
Issue number | 5 |
DOIs |
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State | Published - Sep 1 2012 |
ASJC Scopus subject areas
- Nephrology