Role changes of Β-catenin in kidney injury and repair

Jianping Peng, Zheng Dong

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of Β-catenin in acute kidney injury. Although Β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, Β-catenin suppresses wound healing. Moreover, continuous activation of Β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by Β-catenin and related signaling in kidney injury, repair, and fibrosis.

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalKidney International
Volume82
Issue number5
DOIs
StatePublished - Sep 1 2012

ASJC Scopus subject areas

  • Nephrology

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