Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of Β-catenin in acute kidney injury. Although Β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, Β-catenin suppresses wound healing. Moreover, continuous activation of Β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by Β-catenin and related signaling in kidney injury, repair, and fibrosis.
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