Role changes of Β-catenin in kidney injury and repair

Jianping Peng, Zheng Dong

Research output: Contribution to journalComment/debate

9 Citations (Scopus)

Abstract

Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of Β-catenin in acute kidney injury. Although Β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, Β-catenin suppresses wound healing. Moreover, continuous activation of Β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by Β-catenin and related signaling in kidney injury, repair, and fibrosis.

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalKidney International
Volume82
Issue number5
DOIs
StatePublished - Sep 1 2012

Fingerprint

Catenins
Kidney
Wounds and Injuries
Fibrosis
Acute Kidney Injury
Wound Healing

ASJC Scopus subject areas

  • Nephrology

Cite this

Role changes of Β-catenin in kidney injury and repair. / Peng, Jianping; Dong, Zheng.

In: Kidney International, Vol. 82, No. 5, 01.09.2012, p. 509-511.

Research output: Contribution to journalComment/debate

Peng, Jianping ; Dong, Zheng. / Role changes of Β-catenin in kidney injury and repair. In: Kidney International. 2012 ; Vol. 82, No. 5. pp. 509-511.
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