TY - JOUR
T1 - Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome
AU - Kahsar-Miller, Melissa
AU - Boots, Larry R.
AU - Bartolucci, Alfred
AU - Azziz, Ricardo
N1 - Funding Information:
Supported by grant RO1-HD29364 from the National Institutes of Health, Bethesda, Maryland (R.A.).
PY - 2004/10
Y1 - 2004/10
N2 - We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17α, and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5′ promoter region, plays a significant role in the adrenal androgen excess of PCOS.
AB - We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17α, and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5′ promoter region, plays a significant role in the adrenal androgen excess of PCOS.
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U2 - 10.1016/j.fertnstert.2004.05.068
DO - 10.1016/j.fertnstert.2004.05.068
M3 - Article
C2 - 15482786
AN - SCOPUS:5144219562
SN - 0015-0282
VL - 82
SP - 973
EP - 975
JO - Fertility and sterility
JF - Fertility and sterility
IS - 4
ER -