Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome

Melissa Kahsar-Miller, Larry R. Boots, Alfred Bartolucci, Ricardo Azziz

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17α, and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5′ promoter region, plays a significant role in the adrenal androgen excess of PCOS.

Original languageEnglish (US)
Pages (from-to)973-975
Number of pages3
JournalFertility and sterility
Volume82
Issue number4
DOIs
StatePublished - Oct 1 2004

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Steroid 17-alpha-Hydroxylase
Dehydroepiandrosterone Sulfate
Polycystic Ovary Syndrome
Genetic Promoter Regions
Androgens
Genes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. / Kahsar-Miller, Melissa; Boots, Larry R.; Bartolucci, Alfred; Azziz, Ricardo.

In: Fertility and sterility, Vol. 82, No. 4, 01.10.2004, p. 973-975.

Research output: Contribution to journalArticle

Kahsar-Miller, Melissa ; Boots, Larry R. ; Bartolucci, Alfred ; Azziz, Ricardo. / Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. In: Fertility and sterility. 2004 ; Vol. 82, No. 4. pp. 973-975.
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