Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice

Chan Ho Hwang, Dayong Guo, Marie A. Harris, Omar Howard, Yuji Mishina, Lin Gan, Stephen E. Harris, Doris K. Wu

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, Bmp2 is expressed transiently in nascent cochlear hair cells. To investigate whether Noggin normally modulates the levels of Bmp2 for hair cell formation, we deleted Bmp2 in the cochlear hair cells using two cre strains, Foxg1cre/+ and Gfi1cre/+. Bmp2 conditional knockout cochleae generated using these two cre strains show normal hair cells. Furthermore, Gfi1cre/+;Bmp2lox/- mice are viable and have largely normal hearing. The combined results of Noggin and Bmp2 mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4.

Original languageEnglish (US)
Pages (from-to)505-513
Number of pages9
JournalDevelopmental Dynamics
Volume239
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Keywords

  • Bmp2
  • Cochlea
  • Foxg1-cre
  • Gfi1-cre
  • Hair cell
  • Hearing
  • Mouse
  • Noggin

ASJC Scopus subject areas

  • Developmental Biology

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  • Cite this

    Hwang, C. H., Guo, D., Harris, M. A., Howard, O., Mishina, Y., Gan, L., Harris, S. E., & Wu, D. K. (2010). Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice. Developmental Dynamics, 239(2), 505-513. https://doi.org/10.1002/dvdy.22200