Abstract
Cerebral lateralization may be important in neural control of immune function. Animal studies have demonstrated differential effects of left and right brain lesions on immune function, but human studies are inconclusive. Here, we show that resections in the language dominant hemisphere of patients with epilepsy reduce lymphocytes, total T cells, and helper T cells. In contrast, resections in the language nondominant hemisphere increased the same cellular elements. T-cell responses to mitogens and microbial antigens were not differentially affected. Left/right arm histamine skin response ratios were altered in patients with left cerebral epileptic focus, and flare skin responses were reduced by left cerebral resections in contrast with an increase after right cerebral resections. The findings demonstrate a differential role of the left and right cerebral hemispheres on immune functions in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 840-844 |
| Number of pages | 5 |
| Journal | Annals of Neurology |
| Volume | 55 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2004 |
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ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Role of cerebral lateralization in control of immune processes in humans. / Meador, Kimford J.; Loring, David W.; Ray, Patty G.; Helman, Sandra W.; Vazquez, Blanca R.; Neveu, Pierre J.
In: Annals of Neurology, Vol. 55, No. 6, 01.06.2004, p. 840-844.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of cerebral lateralization in control of immune processes in humans
AU - Meador, Kimford J.
AU - Loring, David W.
AU - Ray, Patty G.
AU - Helman, Sandra W.
AU - Vazquez, Blanca R.
AU - Neveu, Pierre J.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - Cerebral lateralization may be important in neural control of immune function. Animal studies have demonstrated differential effects of left and right brain lesions on immune function, but human studies are inconclusive. Here, we show that resections in the language dominant hemisphere of patients with epilepsy reduce lymphocytes, total T cells, and helper T cells. In contrast, resections in the language nondominant hemisphere increased the same cellular elements. T-cell responses to mitogens and microbial antigens were not differentially affected. Left/right arm histamine skin response ratios were altered in patients with left cerebral epileptic focus, and flare skin responses were reduced by left cerebral resections in contrast with an increase after right cerebral resections. The findings demonstrate a differential role of the left and right cerebral hemispheres on immune functions in humans.
AB - Cerebral lateralization may be important in neural control of immune function. Animal studies have demonstrated differential effects of left and right brain lesions on immune function, but human studies are inconclusive. Here, we show that resections in the language dominant hemisphere of patients with epilepsy reduce lymphocytes, total T cells, and helper T cells. In contrast, resections in the language nondominant hemisphere increased the same cellular elements. T-cell responses to mitogens and microbial antigens were not differentially affected. Left/right arm histamine skin response ratios were altered in patients with left cerebral epileptic focus, and flare skin responses were reduced by left cerebral resections in contrast with an increase after right cerebral resections. The findings demonstrate a differential role of the left and right cerebral hemispheres on immune functions in humans.
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UR - http://www.scopus.com/inward/citedby.url?scp=2542546672&partnerID=8YFLogxK
U2 - 10.1002/ana.20105
DO - 10.1002/ana.20105
M3 - Article
C2 - 15174018
AN - SCOPUS:2542546672
VL - 55
SP - 840
EP - 844
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 6
ER -