Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy

B R Achyut, Uday C Ghoshal, Nikhil Moorchung, Balraj Mittal

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Abstract

In India, the role of host genetic factors is poorly studied for Helicobacter pylori associated diseases. Therefore, we evaluated the association of functionally relevant COX-2 gene polymorphisms (-765 G>C and +8473 T>C) in gastritis and precancerous lesions susceptibility. After upper GI endoscopy, 130 rapid urease test positive patients with non-ulcer dyspepsia, also showed positivity for H. pylori using modified Geimsa staining and anti-CagA IgG serology were included. All patients and 260 asymptomatic controls were genotyped for COX-2 variations using PCR-RFLP. COX-2 -765 (GC+CC) genotypes, -765 C allele, +8473 CC genotype, +8473 (TC+CC) genotypes, +8473 C allele, and variant haplotypes imparted high risk for gastritis (P = 0.036, OR = 1.82; P = 0.007, 1.92; P = 0.025, OR = 2.13; P = 0.017, OR = 1.80; P = 0.017, OR = 1.45; P = 0.010, OR = 2.40; P = 0.023, OR = 1.50 and P = 0.012, OR = 2.20 folds, respectively). In contrast, COX-2 -765 C allele carriers had low risk for lymphocyte (P = 0.020, OR = 0.35), plasma cell infiltrations (P = 0.016, OR = 0.33), and gastric atrophy (GA) development (P = 0.019, OR = 0.35). In conclusion, COX-2 variant allele/genotype/haplotype carriers may be at high risk for gastritis. However, COX-2 -765 C allele carriers may be at low risk for GA development.

Original languageEnglish (US)
Pages (from-to)103-9
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume321
Issue number1-2
DOIs
StatePublished - Jan 2009
Externally publishedYes

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Keywords

  • Adult
  • Cyclooxygenase 2
  • Gastritis, Atrophic
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Helicobacter Infections
  • Helicobacter pylori
  • Humans
  • India
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Precancerous Conditions
  • Journal Article
  • Research Support, Non-U.S. Gov't

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