Role of GATA-4 in differentiation and survival of bone marrow mesenchymal stem cells

Meifeng Xu, Ronald W. Millard, Muhammad Ashraf

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

Cell and tissue regeneration is a relatively new research field and it incorporates a novel application of molecular genetics. Combinatorial approaches for stem-cell-based therapies wherein guided differentiation into cardiac lineage cells and cells secreting paracrine factors may be necessary to overcome the limitations and shortcomings of a singular approach. GATA-4, a GATA zinc-finger transcription factor family member, has been shown to regulate differentiation, growth, and survival of a wide range of cell types. In this chapter, we discuss whether overexpression of GATA-4 increases mesenchymal stem cell (MSC) transdifferentiation into cardiac phenotype and enhances the MSC secretome, thereby increasing cell survival and promoting postinfarction cardiac angiogenesis. MSCs engineered with GATA-4 enhance their capacity to differentiate into cardiac cell phenotypes, improve survival of the cardiac progenitor cells and their offspring, and modulate the paracrine activity of stem cells to support their angiomyogenic potential and cardioprotective effects.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages217-241
Number of pages25
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
Volume111
ISSN (Print)1877-1173

Keywords

  • Angiogenesis
  • Cell survival
  • GATA-4
  • Genetic engineering
  • Stem cell
  • Transdifferentiation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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