Role of Gene-Stress Interactions in Gene-Finding Studies

Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.J.H. Penninx, Harriëtte Riese, Catharina A. Hartman

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Identification of genetic variants underlying common complex traits and diseases can be viewed as a three-stage process that jump-started with the sequencing of the human genome. The second phase, characterization of genetic variants in different human populations, has shown major progress in recent years. The increased availability of single nucleotide polymorphisms (SNPs) has already spawned two important developments in genetic association studies. Increasingly, rather than focusing on one or two functional SNPs, candidate gene studies consider all variants within the gene jointly. The second development is that of the whole genome association study. This chapter illustrates two distinct ways in which gene-stress interactions may aid such gene finding studies. We have recently shown for heart rate variability-an index of autonomic dysfunction related to both psychopathology and cardiovascular disease-that exposure to an acute stressful challenge in a standardized lab setting may produce a more heritable endophenotype, facilitating identification of underlying genes. The second example shows how the creation of a cumulative index of chronic stress based on multiple questionnaire- and interview-based measures of stress exposure may be applied in a genomewide association study of (high) blood pressure to find genes that only come to expression in stressful environments. We conclude that investigation of gene-environment interactions in the context of both gene- and genome-wide association studies may offer important advantages in gene finding efforts for complex traits and diseases.

Original languageEnglish (US)
Title of host publicationGenetic Effects on Environmental Vulnerability to Disease
Publisherwiley
Pages71-82
Number of pages12
ISBN (Electronic)9780470696781
ISBN (Print)9780470777800
DOIs
Publication statusPublished - Aug 12 2008

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Keywords

  • Blood pressure
  • Endophenotype
  • Gene finding
  • Gene-stress interaction
  • Gene-wide candidate gene study
  • Genome-wide association
  • Heart rate variability
  • Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Snieder, H., Wang, X., Lagou, V., Penninx, B. W. J. H., Riese, H., & Hartman, C. A. (2008). Role of Gene-Stress Interactions in Gene-Finding Studies. In Genetic Effects on Environmental Vulnerability to Disease (pp. 71-82). wiley. https://doi.org/10.1002/9780470696781.ch6