Role of hydrogen sulfide in brain synaptic remodeling

Pradip Kumar Kamat, Anuradha Kalani, Neetu Tyagi

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Scopus citations

Abstract

Synapses are the functional connection between neurons which are necessary for the transfer of electric activity or chemical activity from one cell to another. Synapses are formed by the pre- and postsynaptic membrane which communicates between pre- and postneurons while a neurochemical modulator is operated in this process. H2S has been known as a toxic gas with rotten eggs smell. However, increasing number of researches show that it regulate a variety of physiological and pathological processes in mammals. Hence, H2S is a physiologically important molecule and has been referred to as the third gaseous molecule alongside carbon monoxide and nitric oxide. The previous era has made an exponential development in the physiological and pathological significance of H2S. Specifically, in the central nervous system, H2S facilitates long-term potentiation and regulates intracellular calcium concentration in brain cells. We as well as others have also shown that H2S has antioxidant, antiapoptotic, and anti-inflammatory properties against various neurodegenerative disorders such as stroke, Alzheimer's disease, and vascular dementia. In this chapter, we highlight the current knowledge of H2S and its neuroprotective effects with a special emphasis on synaptic remodeling.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
Pages207-229
Number of pages23
DOIs
StatePublished - 2015
Externally publishedYes

Publication series

NameMethods in Enzymology
Volume555
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Astrocyte
  • Brain
  • Hydrogen sulfide
  • LTP
  • NMDA
  • Synapse

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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