Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview

Babatunde Fariyike, Quante Singleton, David M Hunter, William D. Hill, Carlos M Isales, Mark W Hamrick, Sadanand T Fulzele

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

MicroRNA's are small non-coding RNAs that regulate the expression of genes by targeting the 3’ UTR's of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathological disease processes. Additionally, with aging, it is noted that there is dysregulation in the normal function of stem cell differentiation, bone formation/degradation, chondrocyte function, and muscle degeneration. Due to the change in expression of miRNA in degenerative musculoskeletal pathology, it is believed that these molecules may be at least partially responsible for cellular dysfunction. A number of miRNAs have already been identified to play a role in osteoarthritis, osteoporosis and sarcopenia. One miRNA that has become of interest recently is miRNA 141. The purpose of this article is to review the current literature available on miRNA 141 and how it could play a role in osteoporosis, osteoarthritis and musculoskeletal pathology overall.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalMechanisms of Ageing and Development
Volume178
DOIs
StatePublished - Mar 1 2019

Fingerprint

Musculoskeletal System
MicroRNAs
Osteogenesis
Osteoarthritis
Osteoporosis
Cell Differentiation
Pathology
Sarcopenia
Chondrogenesis
Small Untranslated RNA
Gene Targeting
3' Untranslated Regions
Pathologic Processes
Chondrocytes
Mesenchymal Stromal Cells
Stem Cells
Apoptosis
Muscles
Messenger RNA

Keywords

  • MiR-200 family
  • MicroRNA-141
  • aging
  • musculoskeletal

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Cite this

Role of MicroRNA-141 in the Aging Musculoskeletal System : A Current Overview. / Fariyike, Babatunde; Singleton, Quante; Hunter, David M; Hill, William D.; Isales, Carlos M; Hamrick, Mark W; Fulzele, Sadanand T.

In: Mechanisms of Ageing and Development, Vol. 178, 01.03.2019, p. 9-15.

Research output: Contribution to journalReview article

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AU - Isales, Carlos M

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