Role of nitric oxide in renal papillary blood flow and sodium excretion

David L. Mattson, Richard J. Roman, Allen W. Cowley

Research output: Contribution to journalArticle

Abstract

Renal medullary interstitial infusion of NG-nitro-L-arginine (120 μg/hr, n = 7) decreased papillary blood flow to 71±5% of control without altering outer cortical flow. Before NG-nitro-L-arginine infusion, interstitial acetylcholine administration (200 μg/hr) increased cortical and papillary blood flow to 134±6% and 113±2% of control, respectively. After NG-nitro-L-arginine administration, the vasodilator response to acetylcholine was abolished. In clearance experiments, renal medullary infusion of NG-nitro-L-arginine (120 μg/hr, n = 7) significantly decreased total renal blood flow by 10%, renal interstitial fluid pressure by 23%, sodium excretion by 34%, and urine flow by 39% without altering glomerular filtration rate, fractional sodium and water excretion, blood pressure, or urine osmolality. These data indicate that selective inhibition of nitric oxide in the renal medullary vasculature reduces papillary blood flow, which is associated with decreased sodium and water excretion. We conclude that nitric oxide exerts a tonic influence on the renal medullary circulation.

Original languageEnglish (US)
Pages (from-to)766-769
Number of pages4
JournalHypertension
Volume19
Issue number6
DOIs
StatePublished - Jun 1992
Externally publishedYes

Fingerprint

Renal Circulation
Nitroarginine
Nitric Oxide
Sodium
Kidney
Acetylcholine
Urine
Water
Extracellular Fluid
Glomerular Filtration Rate
Vasodilator Agents
Osmolar Concentration
Blood Pressure
Pressure

Keywords

  • arginine
  • endothelium-derived relaxing factor
  • flowmeters
  • kidney
  • kidney medulla
  • nitric oxide
  • renal circulation
  • urine

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Role of nitric oxide in renal papillary blood flow and sodium excretion. / Mattson, David L.; Roman, Richard J.; Cowley, Allen W.

In: Hypertension, Vol. 19, No. 6, 06.1992, p. 766-769.

Research output: Contribution to journalArticle

Mattson, David L. ; Roman, Richard J. ; Cowley, Allen W. / Role of nitric oxide in renal papillary blood flow and sodium excretion. In: Hypertension. 1992 ; Vol. 19, No. 6. pp. 766-769.
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