Role of oxidatively modified LDL in atherosclerosis

Urs P. Steinbrecher, Hanfang Zhang, Marilee Lougheed

Research output: Contribution to journalArticle

549 Scopus citations

Abstract

Oxidative modification of LDL is accompanied by a number of compositional and structural changes, including increased electrophoretic mobility, increased density, fragmentation of apolipoprotein B, hydrolysis of phosphatidylcholine, derivatization of lysine amino groups, and generation of lfuorescent adducts due to covalent binding of lipid oxidation products to apo B. In addition, oxidation of LDL has been shown to result in numerous changes in its biologic properties that could have pathogenetic imortance, including accelerated uptake in macrophages, cytotoxicity, and chemotactic activity for monocytes. The present article summarrizes very recent developments related to the mechanism of oxidation of LDL by cells, receptor-mediated uptake of oxidized LDL in macrophages, the mechanism of phosphatidylcholine hydrolysis during LDL oxidation, and other biologic actions of oxidized LDL including cytotoxicity, altered eicosanoid metabolism, and effects on the secretion of growth factors and chemotactic factors. In addition, this review will exzmine the evidence for the presence of oxidized LDL in vivo and the evidence that oxidized LDL plays a pathogenetic role in atherosclerosis.

Original languageEnglish (US)
Pages (from-to)155-168
Number of pages14
JournalFree Radical Biology and Medicine
Volume9
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • Aterosclerosis
  • Free radicals
  • Lipid peroxidation
  • Macrophages
  • Oxidized LDL
  • Scavenger receptor

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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