Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma

Tracy L. McGaha, Constantin A. Bona

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

IL-4 is potentially a major profibrogenic cytokine upregulating the expression of collagen genes. In vivo studies have shown that the disruption of STAT6, IL-4R, IL-4 or transforming growth factor-β (TGF-β) genes in TSK mice, which develop scleroderma-like syndrome, prevented the occurrence of skin sclerosis and of autoantibodies. Additionally, it is known that the homozygosity of TSK mutation is lethal and the embryos die by day 7-8 of pregnancy. The disruption of IL-4 gene rescued from death TSK/TSK mice suggesting a role for IL-4 in embryonic development. Since TGF-β should compensate the lack of IL-4 on regulation of collagen gene expression, we have studied the effect of IL-4 on the expression of TGF-β gene. Our results showed IL-4 dependence of the transcription of TGF-β gene and that in both TSK/+ and TSK/TSK IL-4-/- mice the expression of TGF-β gene is impaired.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalAutoimmunity Reviews
Volume1
Issue number3
DOIs
StatePublished - Jan 1 2002

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Interleukin-4
Cytokines
Transforming Growth Factors
T-Lymphocytes
Genes
Collagen
Gene Expression Regulation
Sclerosis
Autoantibodies
Embryonic Development
Embryonic Structures
Gene Expression
Pregnancy
Skin
Mutation

Keywords

  • Cytokines
  • Scleroderma
  • Tight skin mice

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma. / McGaha, Tracy L.; Bona, Constantin A.

In: Autoimmunity Reviews, Vol. 1, No. 3, 01.01.2002, p. 174-181.

Research output: Contribution to journalReview article

McGaha, Tracy L. ; Bona, Constantin A. / Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma. In: Autoimmunity Reviews. 2002 ; Vol. 1, No. 3. pp. 174-181.
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