Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma

Tracy L. McGaha; Constantin A. Bona

doi:10.1016/S1568-9972(02)00027-7

Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma

Tracy L. McGaha, Constantin A. Bona

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

IL-4 is potentially a major profibrogenic cytokine upregulating the expression of collagen genes. In vivo studies have shown that the disruption of STAT6, IL-4R, IL-4 or transforming growth factor-β (TGF-β) genes in TSK mice, which develop scleroderma-like syndrome, prevented the occurrence of skin sclerosis and of autoantibodies. Additionally, it is known that the homozygosity of TSK mutation is lethal and the embryos die by day 7-8 of pregnancy. The disruption of IL-4 gene rescued from death TSK/TSK mice suggesting a role for IL-4 in embryonic development. Since TGF-β should compensate the lack of IL-4 on regulation of collagen gene expression, we have studied the effect of IL-4 on the expression of TGF-β gene. Our results showed IL-4 dependence of the transcription of TGF-β gene and that in both TSK/+ and TSK/TSK IL-4-/- mice the expression of TGF-β gene is impaired.

Original language	English (US)
Pages (from-to)	174-181
Number of pages	8
Journal	Autoimmunity Reviews
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/S1568-9972(02)00027-7
State	Published - May 2002
Externally published	Yes

Keywords

Cytokines
Scleroderma
Tight skin mice

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S1568-9972(02)00027-7

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@article{3d11777ae18f46d4ba751afe4d3c5454,

title = "Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma",

abstract = "IL-4 is potentially a major profibrogenic cytokine upregulating the expression of collagen genes. In vivo studies have shown that the disruption of STAT6, IL-4R, IL-4 or transforming growth factor-β (TGF-β) genes in TSK mice, which develop scleroderma-like syndrome, prevented the occurrence of skin sclerosis and of autoantibodies. Additionally, it is known that the homozygosity of TSK mutation is lethal and the embryos die by day 7-8 of pregnancy. The disruption of IL-4 gene rescued from death TSK/TSK mice suggesting a role for IL-4 in embryonic development. Since TGF-β should compensate the lack of IL-4 on regulation of collagen gene expression, we have studied the effect of IL-4 on the expression of TGF-β gene. Our results showed IL-4 dependence of the transcription of TGF-β gene and that in both TSK/+ and TSK/TSK IL-4-/- mice the expression of TGF-β gene is impaired.",

keywords = "Cytokines, Scleroderma, Tight skin mice",

author = "McGaha, {Tracy L.} and Bona, {Constantin A.}",

note = "Funding Information: This work was supported, in part, by NIH grant P01AI24671-14 and a grant from The Scleroderma Foundation. ",

year = "2002",

month = may,

doi = "10.1016/S1568-9972(02)00027-7",

language = "English (US)",

volume = "1",

pages = "174--181",

journal = "Autoimmunity Reviews",

issn = "1568-9972",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma

AU - McGaha, Tracy L.

AU - Bona, Constantin A.

N1 - Funding Information: This work was supported, in part, by NIH grant P01AI24671-14 and a grant from The Scleroderma Foundation.

PY - 2002/5

Y1 - 2002/5

N2 - IL-4 is potentially a major profibrogenic cytokine upregulating the expression of collagen genes. In vivo studies have shown that the disruption of STAT6, IL-4R, IL-4 or transforming growth factor-β (TGF-β) genes in TSK mice, which develop scleroderma-like syndrome, prevented the occurrence of skin sclerosis and of autoantibodies. Additionally, it is known that the homozygosity of TSK mutation is lethal and the embryos die by day 7-8 of pregnancy. The disruption of IL-4 gene rescued from death TSK/TSK mice suggesting a role for IL-4 in embryonic development. Since TGF-β should compensate the lack of IL-4 on regulation of collagen gene expression, we have studied the effect of IL-4 on the expression of TGF-β gene. Our results showed IL-4 dependence of the transcription of TGF-β gene and that in both TSK/+ and TSK/TSK IL-4-/- mice the expression of TGF-β gene is impaired.

AB - IL-4 is potentially a major profibrogenic cytokine upregulating the expression of collagen genes. In vivo studies have shown that the disruption of STAT6, IL-4R, IL-4 or transforming growth factor-β (TGF-β) genes in TSK mice, which develop scleroderma-like syndrome, prevented the occurrence of skin sclerosis and of autoantibodies. Additionally, it is known that the homozygosity of TSK mutation is lethal and the embryos die by day 7-8 of pregnancy. The disruption of IL-4 gene rescued from death TSK/TSK mice suggesting a role for IL-4 in embryonic development. Since TGF-β should compensate the lack of IL-4 on regulation of collagen gene expression, we have studied the effect of IL-4 on the expression of TGF-β gene. Our results showed IL-4 dependence of the transcription of TGF-β gene and that in both TSK/+ and TSK/TSK IL-4-/- mice the expression of TGF-β gene is impaired.

KW - Cytokines

KW - Scleroderma

KW - Tight skin mice

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U2 - 10.1016/S1568-9972(02)00027-7

DO - 10.1016/S1568-9972(02)00027-7

M3 - Review article

C2 - 12849012

AN - SCOPUS:1542614155

SN - 1568-9972

VL - 1

SP - 174

EP - 181

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 3

ER -

Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma

Abstract

Keywords

ASJC Scopus subject areas

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