Role of renal medullary blood flow in the development of L-NAME hypertension in rats

K. Nakanishi, D. L. Mattson, A. W. Cowley

Research output: Contribution to journalArticle

Abstract

The effect of chronic intravenous infusion of the nitric oxide inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 8.6 mg · kg-1 · day-1) on blood pressure, intrarenal blood flow distribution, and sodium and water balance was studied in conscious rats. On the 1st day of intravenous L-NAME infusion, renal medullary blood flow was reduced by 22%, renal cortical blood flow was unaltered, ~1 meq of sodium and 12 ml of water were retained, and blood pressure increased from 96 ± 2 to 118 ± 2 mmHg. Medullary blood flow was maintained at this decreased level, sodium continued to be retained, body weight continued to increase, and blood pressure remained elevated for the 5 days of L-NAME infusion. During the postcontrol period, blood flow in the renal medulla returned to levels not significantly different from control; the animals went into negative sodium balance and stopped gaining weight, and blood pressure returned to control. The present experiments indicate that decreased renal medullary blood flow and retention of sodium and water play an important role in the development of hypertension during chronic systemic L-NAME administration despite no measurable changes in renal cortical blood flow.

Original languageEnglish (US)
Pages (from-to)R317-R323
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume268
Issue number2 37-2
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Renal Circulation
NG-Nitroarginine Methyl Ester
Sodium
Hypertension
Blood Pressure
Water
Intravenous Infusions
Nitric Oxide
Body Weight
Weights and Measures

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Role of renal medullary blood flow in the development of L-NAME hypertension in rats. / Nakanishi, K.; Mattson, D. L.; Cowley, A. W.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 268, No. 2 37-2, 01.01.1995, p. R317-R323.

Research output: Contribution to journalArticle

@article{8bc83334bd1445e682f57711336c72d1,
title = "Role of renal medullary blood flow in the development of L-NAME hypertension in rats",
abstract = "The effect of chronic intravenous infusion of the nitric oxide inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 8.6 mg · kg-1 · day-1) on blood pressure, intrarenal blood flow distribution, and sodium and water balance was studied in conscious rats. On the 1st day of intravenous L-NAME infusion, renal medullary blood flow was reduced by 22{\%}, renal cortical blood flow was unaltered, ~1 meq of sodium and 12 ml of water were retained, and blood pressure increased from 96 ± 2 to 118 ± 2 mmHg. Medullary blood flow was maintained at this decreased level, sodium continued to be retained, body weight continued to increase, and blood pressure remained elevated for the 5 days of L-NAME infusion. During the postcontrol period, blood flow in the renal medulla returned to levels not significantly different from control; the animals went into negative sodium balance and stopped gaining weight, and blood pressure returned to control. The present experiments indicate that decreased renal medullary blood flow and retention of sodium and water play an important role in the development of hypertension during chronic systemic L-NAME administration despite no measurable changes in renal cortical blood flow.",
author = "K. Nakanishi and Mattson, {D. L.} and Cowley, {A. W.}",
year = "1995",
month = "1",
day = "1",
language = "English (US)",
volume = "268",
pages = "R317--R323",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "2 37-2",

}

TY - JOUR

T1 - Role of renal medullary blood flow in the development of L-NAME hypertension in rats

AU - Nakanishi, K.

AU - Mattson, D. L.

AU - Cowley, A. W.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The effect of chronic intravenous infusion of the nitric oxide inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 8.6 mg · kg-1 · day-1) on blood pressure, intrarenal blood flow distribution, and sodium and water balance was studied in conscious rats. On the 1st day of intravenous L-NAME infusion, renal medullary blood flow was reduced by 22%, renal cortical blood flow was unaltered, ~1 meq of sodium and 12 ml of water were retained, and blood pressure increased from 96 ± 2 to 118 ± 2 mmHg. Medullary blood flow was maintained at this decreased level, sodium continued to be retained, body weight continued to increase, and blood pressure remained elevated for the 5 days of L-NAME infusion. During the postcontrol period, blood flow in the renal medulla returned to levels not significantly different from control; the animals went into negative sodium balance and stopped gaining weight, and blood pressure returned to control. The present experiments indicate that decreased renal medullary blood flow and retention of sodium and water play an important role in the development of hypertension during chronic systemic L-NAME administration despite no measurable changes in renal cortical blood flow.

AB - The effect of chronic intravenous infusion of the nitric oxide inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; 8.6 mg · kg-1 · day-1) on blood pressure, intrarenal blood flow distribution, and sodium and water balance was studied in conscious rats. On the 1st day of intravenous L-NAME infusion, renal medullary blood flow was reduced by 22%, renal cortical blood flow was unaltered, ~1 meq of sodium and 12 ml of water were retained, and blood pressure increased from 96 ± 2 to 118 ± 2 mmHg. Medullary blood flow was maintained at this decreased level, sodium continued to be retained, body weight continued to increase, and blood pressure remained elevated for the 5 days of L-NAME infusion. During the postcontrol period, blood flow in the renal medulla returned to levels not significantly different from control; the animals went into negative sodium balance and stopped gaining weight, and blood pressure returned to control. The present experiments indicate that decreased renal medullary blood flow and retention of sodium and water play an important role in the development of hypertension during chronic systemic L-NAME administration despite no measurable changes in renal cortical blood flow.

UR - http://www.scopus.com/inward/record.url?scp=0028945187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028945187&partnerID=8YFLogxK

M3 - Article

C2 - 7864223

AN - SCOPUS:0028945187

VL - 268

SP - R317-R323

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 2 37-2

ER -