Role of renal TRP channels in physiology and pathology

Viktor Tomilin, Mykola Mamenko, Oleg Zaika, Oleh Pochynyuk

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Kidneys critically contribute to the maintenance of whole-body homeostasis by governing water and electrolyte balance, controlling extracellular fluid volume, plasma osmolality, and blood pressure. Renal function is regulated by numerous systemic endocrine and local mechanical stimuli. Kidneys possess a complex network of membrane receptors, transporters, and ion channels which allows responding to this wide array of signaling inputs in an integrative manner. Transient receptor potential (TRP) channel family members with diverse modes of activation, varied permeation properties, and capability to integrate multiple downstream signals are pivotal molecular determinants of renal function all along the nephron. This review summarizes experimental data on the role of TRP channels in a healthy mammalian kidney and discusses their involvement in renal pathologies.

Original languageEnglish (US)
Pages (from-to)371-383
Number of pages13
JournalSeminars in Immunopathology
Volume38
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • Epithelial transport
  • TRPC6
  • TRPM6
  • TRPP2
  • TRPV4
  • TRPV5
  • glomerular disease
  • mechanosensitivity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Role of renal TRP channels in physiology and pathology'. Together they form a unique fingerprint.

  • Cite this