Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics

Joo Sung Kim, Jiaqi Li, If H.A. Barnes, David A. Baltzegar, Mohanasundari Pajaniappan, Thomas W. Cullen, M. Stephen Trent, Christopher M. Burns, Stuart A Thompson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Δcj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

Original languageEnglish (US)
Pages (from-to)6524-6529
Number of pages6
JournalJournal of Bacteriology
Volume190
Issue number19
DOIs
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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    Kim, J. S., Li, J., Barnes, I. H. A., Baltzegar, D. A., Pajaniappan, M., Cullen, T. W., Trent, M. S., Burns, C. M., & Thompson, S. A. (2008). Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics. Journal of Bacteriology, 190(19), 6524-6529. https://doi.org/10.1128/JB.00765-08