Role of the JAK/STAT signaling pathway in diabetic nephropathy

Mario B Marrero, Amy K. Banes-Berceli, David M. Stern, Douglas C. Eaton

Research output: Contribution to journalReview article

126 Citations (Scopus)

Abstract

Excessive cellular growth is a major contributor to pathological changes associated with diabetic nephropathy. In particular, high glucose-induced growth of glomerular mesangial cells is a characteristic feature of diabetes-induced renal complications. Glomerular mesangial cells respond to traditional growth factors, although in diabetes this occurs in the context of an environment enriched in both circulating vasoactive mediators and high glucose. For example, the vasoactive peptide ANG II has been implicated in the pathogenesis of diabetic renal disease, and recent findings suggest that high glucose and ANG II activate intracellular signaling processes, including the polyol pathway and generation of reactive oxygen species. These pathways activate the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling cascades in glomerular mesangial cells. Activation of the JAK/STAT signaling cascade can stimulate excessive proliferation and growth of glomerular mesangial cells, contributing to diabetic nephropathy. This review focuses on some of the key elements in the diabetic microenvironment, especially high glucose and the accumulation of advanced glycoxidation end products and considers their impact on ANG II and other vasoactive peptide-mediated signaling events in vitro and in vivo.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume290
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Janus Kinases
Mesangial Cells
Diabetic Nephropathies
Transducers
Glucose
Growth
Kidney
Peptides
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins

Keywords

  • ANG II
  • Advanced glycoxidation end products
  • Glomerular mesangial cells
  • High glucose

ASJC Scopus subject areas

  • Physiology

Cite this

Role of the JAK/STAT signaling pathway in diabetic nephropathy. / Marrero, Mario B; Banes-Berceli, Amy K.; Stern, David M.; Eaton, Douglas C.

In: American Journal of Physiology - Renal Physiology, Vol. 290, No. 4, 01.04.2006.

Research output: Contribution to journalReview article

Marrero, Mario B ; Banes-Berceli, Amy K. ; Stern, David M. ; Eaton, Douglas C. / Role of the JAK/STAT signaling pathway in diabetic nephropathy. In: American Journal of Physiology - Renal Physiology. 2006 ; Vol. 290, No. 4.
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