Role of TNF-α in vascular dysfunction

Hanrui Zhang, Yoonjung Park, Junxi Wu, Xiu Ping Chen, Sewon Lee, Jiyeon Yang, Kevin C. Dellsperger, Cuihua Zhang

Research output: Contribution to journalReview article

366 Citations (Scopus)

Abstract

Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) and EDHF (endothelium-dependent hyperpolarizing factor). Vascular dysfunction or injury induced by aging, smoking, inflammation, trauma, hyperlipidaemia and hyperglycaemia are among a myriad of risk factors that may contribute to the pathogenesis of many cardiovascular diseases, such as hypertension, diabetes and atherosclerosis. However, the exact mechanisms underlying the impaired vascular activity remain unresolved and there is no current scientific consensus. Accumulating evidence suggests that the inflammatory cytokine TNF (tumour necrosis factor)-α plays a pivotal role in the disruption of macrovascular and microvascular circulation both in vivo and in vitro. AGEs (advanced glycation end-products)/RAGE (receptor for AGEs), LOX-1 [lectin-like oxidized low-density lipoprotein receptor-1) and NF-κB (nuclear factor κB) signalling play key roles in TNF-α expression through an increase in circulating and/or local vascular TNF-α production. The increase in TNF-α expression induces the production of ROS (reactive oxygen species), resulting in endothelial dysfunction in many pathophysiological conditions. Lipid metabolism, dietary supplements and physical activity affect TNF-α expression. The interaction between TNF-α and stem cells is also important in terms of vascular repair or regeneration. Careful scrutiny of these factors may help elucidate the mechanisms that induce vascular dysfunction. The focus of the present review is to summarize recent evidence showing the role of TNF-α in vascular dysfunction in cardiovascular disease. We believe these findings may prompt new directions for targeting inflammation in future therapies.

Original languageEnglish (US)
Pages (from-to)219-230
Number of pages12
JournalClinical Science
Volume116
Issue number3
DOIs
StatePublished - Feb 1 2009

Fingerprint

Blood Vessels
Tumor Necrosis Factor-alpha
Endothelium
Class E Scavenger Receptors
Cardiovascular Diseases
Inflammation
Endothelium-Dependent Relaxing Factors
Advanced Glycosylation End Products
Wounds and Injuries
Dietary Supplements
Hyperlipidemias
Lipid Metabolism
Hyperglycemia
Regeneration
Reactive Oxygen Species
Atherosclerosis
Consensus
Stem Cells
Smoking
Cytokines

Keywords

  • Inflammation
  • Macrovascular circulation
  • Microvascular circulation
  • Nitric oxide
  • Reactive oxygen species (ROS)
  • Tumour Necrosis factor-α (TNF-α)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zhang, H., Park, Y., Wu, J., Chen, X. P., Lee, S., Yang, J., ... Zhang, C. (2009). Role of TNF-α in vascular dysfunction. Clinical Science, 116(3), 219-230. https://doi.org/10.1042/CS20080196

Role of TNF-α in vascular dysfunction. / Zhang, Hanrui; Park, Yoonjung; Wu, Junxi; Chen, Xiu Ping; Lee, Sewon; Yang, Jiyeon; Dellsperger, Kevin C.; Zhang, Cuihua.

In: Clinical Science, Vol. 116, No. 3, 01.02.2009, p. 219-230.

Research output: Contribution to journalReview article

Zhang, H, Park, Y, Wu, J, Chen, XP, Lee, S, Yang, J, Dellsperger, KC & Zhang, C 2009, 'Role of TNF-α in vascular dysfunction', Clinical Science, vol. 116, no. 3, pp. 219-230. https://doi.org/10.1042/CS20080196
Zhang H, Park Y, Wu J, Chen XP, Lee S, Yang J et al. Role of TNF-α in vascular dysfunction. Clinical Science. 2009 Feb 1;116(3):219-230. https://doi.org/10.1042/CS20080196
Zhang, Hanrui ; Park, Yoonjung ; Wu, Junxi ; Chen, Xiu Ping ; Lee, Sewon ; Yang, Jiyeon ; Dellsperger, Kevin C. ; Zhang, Cuihua. / Role of TNF-α in vascular dysfunction. In: Clinical Science. 2009 ; Vol. 116, No. 3. pp. 219-230.
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