Running induces widespread structural alterations in the hippocampus and entorhinal cortex

Alexis Michelle Stranahan, David Khalil, Elizabeth Gould

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Physical activity enhances hippocampal function but its effects on neuronal structure remain relatively unexplored outside of the dentate gyrus. Using Golgi impregnation and the lipophilic tracer Dil, we show that long-term voluntary running increases the density of dendritic spines in the entorhinal cortex and hippocampus of adult rats. Exercise was associated with increased dendritic spine density not only in granule neurons of the dentate gyrus, but also in CA1 pyramidal neurons, and in layer III pyramidal neurons of the entorhinal cortex. In the CA1 region, changes in dendritic spine density are accompanied by changes in dendritic arborization and alterations in the morphology of individual spines. These findings suggest that physical activity exerts pervasive effects on neuronal morphology in the hippocampus and one of its afferent populations. These structural changes may contribute to running-induced changes in cognitive function,

Original languageEnglish (US)
Pages (from-to)1017-1022
Number of pages6
JournalHippocampus
Volume17
Issue number11
DOIs
StatePublished - Nov 29 2007

Fingerprint

Dendritic Spines
Entorhinal Cortex
Running
Hippocampus
Pyramidal Cells
Dentate Gyrus
Neuronal Plasticity
Cognition
Spine
Neurons
Population

Keywords

  • CA1 pyramidal cell
  • Dendritic spine
  • Dentate gyrus
  • Physical exercise
  • Plasticity

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Running induces widespread structural alterations in the hippocampus and entorhinal cortex. / Stranahan, Alexis Michelle; Khalil, David; Gould, Elizabeth.

In: Hippocampus, Vol. 17, No. 11, 29.11.2007, p. 1017-1022.

Research output: Contribution to journalArticle

Stranahan, Alexis Michelle ; Khalil, David ; Gould, Elizabeth. / Running induces widespread structural alterations in the hippocampus and entorhinal cortex. In: Hippocampus. 2007 ; Vol. 17, No. 11. pp. 1017-1022.
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