Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice

Meghan Elizabeth McGee Lawrence, Xiaodong Li, Krista L. Bledsoe, Hai Wu, John R. Hawse, Malayannan Subramaniam, David F. Razidlo, Bridget A. Stensgard, Gary S. Stein, Andre J. Van Wijnen, Jane B. Lian, Wei Hsu, Jennifer J. Westendorf

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Runx2 and Axin2 are required for proper skeletal development. Results: Runx2 and Hdac3 repress Axin2 transcription in osteoblasts. Runx2 insufficiency prevents craniosynostosis in Axin2- deficient mice. Conclusion: A Runx2-Axin2 regulatory mechanism controls the pace of calvarial bone formation. Significance: The molecular and functional interplay between Runx2 and Axin2 controls the rate of cranial suture closure. Similar interactions may occur during skeletal development and carcinogenesis.

Original languageEnglish (US)
Pages (from-to)5291-5302
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013
Externally publishedYes

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Core Binding Factor Alpha 1 Subunit
Cranial Sutures
Craniosynostoses
Osteoblasts
Osteogenesis
Carcinogenesis
Transcription
Bone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice. / McGee Lawrence, Meghan Elizabeth; Li, Xiaodong; Bledsoe, Krista L.; Wu, Hai; Hawse, John R.; Subramaniam, Malayannan; Razidlo, David F.; Stensgard, Bridget A.; Stein, Gary S.; Van Wijnen, Andre J.; Lian, Jane B.; Hsu, Wei; Westendorf, Jennifer J.

In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5291-5302.

Research output: Contribution to journalArticle

McGee Lawrence, ME, Li, X, Bledsoe, KL, Wu, H, Hawse, JR, Subramaniam, M, Razidlo, DF, Stensgard, BA, Stein, GS, Van Wijnen, AJ, Lian, JB, Hsu, W & Westendorf, JJ 2013, 'Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice', Journal of Biological Chemistry, vol. 288, no. 8, pp. 5291-5302. https://doi.org/10.1074/jbc.M112.414995
McGee Lawrence, Meghan Elizabeth ; Li, Xiaodong ; Bledsoe, Krista L. ; Wu, Hai ; Hawse, John R. ; Subramaniam, Malayannan ; Razidlo, David F. ; Stensgard, Bridget A. ; Stein, Gary S. ; Van Wijnen, Andre J. ; Lian, Jane B. ; Hsu, Wei ; Westendorf, Jennifer J. / Runx2 protein represses axin2 expression in osteoblasts and is required for craniosynostosis in axin2-deficient mice. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 8. pp. 5291-5302.
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abstract = "Background: Runx2 and Axin2 are required for proper skeletal development. Results: Runx2 and Hdac3 repress Axin2 transcription in osteoblasts. Runx2 insufficiency prevents craniosynostosis in Axin2- deficient mice. Conclusion: A Runx2-Axin2 regulatory mechanism controls the pace of calvarial bone formation. Significance: The molecular and functional interplay between Runx2 and Axin2 controls the rate of cranial suture closure. Similar interactions may occur during skeletal development and carcinogenesis.",
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AU - McGee Lawrence, Meghan Elizabeth

AU - Li, Xiaodong

AU - Bledsoe, Krista L.

AU - Wu, Hai

AU - Hawse, John R.

AU - Subramaniam, Malayannan

AU - Razidlo, David F.

AU - Stensgard, Bridget A.

AU - Stein, Gary S.

AU - Van Wijnen, Andre J.

AU - Lian, Jane B.

AU - Hsu, Wei

AU - Westendorf, Jennifer J.

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