Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes

A Population-Based Analysis

Research output: Contribution to journalArticle

Abstract

Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P =.632). Five-, 10-, and 20-year DSS rates were 81.3% (n = 117), 69.6% (n = 94), and 55.3% (n = 68), respectively. Men (hazard ratio, 4.74; P =.0087) and patients with regional (hazard ratio, 5.59; P =.018) or distant (hazard ratio, 8.9; P =.01) metastases carried a worse prognosis. Five-year DSS was greater in patients with localized disease (96.36%, P <.0001) than those with regional or distant metastases. Treatment with surgery alone had better 10-year DSS (86.3%) compared with treatment with combination radiation and surgery (57.6%) or radiation monotherapy (18.75%, P <.0001). Conclusions: Salivary clear cell carcinoma carries an overall good prognosis. Patients with localized disease and those treated with surgery alone have more favorable prognoses. Male patients and those with regional or distant metastatic disease at time of presentation carry a worse prognosis. Level of Evidence: N/A.

Original languageEnglish (US)
JournalAnnals of Otology, Rhinology and Laryngology
DOIs
StatePublished - Jan 1 2019

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Carcinoma
Population
Survival
Radiation
Neoplasm Metastasis
Kaplan-Meier Estimate
Epidemiology
Survival Rate
Databases
Incidence
Therapeutics
Neoplasms

Keywords

  • End Results
  • Epidemiology
  • Surveillance
  • disease-specific survival
  • hyalinizing clear cell carcinoma
  • population-based
  • salivary clear cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{1df45a2e343b46cf8080fb69ddd012cf,
title = "Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes: A Population-Based Analysis",
abstract = "Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93{\%}, P =.632). Five-, 10-, and 20-year DSS rates were 81.3{\%} (n = 117), 69.6{\%} (n = 94), and 55.3{\%} (n = 68), respectively. Men (hazard ratio, 4.74; P =.0087) and patients with regional (hazard ratio, 5.59; P =.018) or distant (hazard ratio, 8.9; P =.01) metastases carried a worse prognosis. Five-year DSS was greater in patients with localized disease (96.36{\%}, P <.0001) than those with regional or distant metastases. Treatment with surgery alone had better 10-year DSS (86.3{\%}) compared with treatment with combination radiation and surgery (57.6{\%}) or radiation monotherapy (18.75{\%}, P <.0001). Conclusions: Salivary clear cell carcinoma carries an overall good prognosis. Patients with localized disease and those treated with surgery alone have more favorable prognoses. Male patients and those with regional or distant metastatic disease at time of presentation carry a worse prognosis. Level of Evidence: N/A.",
keywords = "End Results, Epidemiology, Surveillance, disease-specific survival, hyalinizing clear cell carcinoma, population-based, salivary clear cell carcinoma",
author = "Sharbel, {Daniel D.} and Unsal, {Aykut A} and Groves, {Michael W} and Albergotti, {William Greer} and Byrd, {James Kenneth}",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/0003489419853597",
language = "English (US)",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",

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TY - JOUR

T1 - Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes

T2 - A Population-Based Analysis

AU - Sharbel, Daniel D.

AU - Unsal, Aykut A

AU - Groves, Michael W

AU - Albergotti, William Greer

AU - Byrd, James Kenneth

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P =.632). Five-, 10-, and 20-year DSS rates were 81.3% (n = 117), 69.6% (n = 94), and 55.3% (n = 68), respectively. Men (hazard ratio, 4.74; P =.0087) and patients with regional (hazard ratio, 5.59; P =.018) or distant (hazard ratio, 8.9; P =.01) metastases carried a worse prognosis. Five-year DSS was greater in patients with localized disease (96.36%, P <.0001) than those with regional or distant metastases. Treatment with surgery alone had better 10-year DSS (86.3%) compared with treatment with combination radiation and surgery (57.6%) or radiation monotherapy (18.75%, P <.0001). Conclusions: Salivary clear cell carcinoma carries an overall good prognosis. Patients with localized disease and those treated with surgery alone have more favorable prognoses. Male patients and those with regional or distant metastatic disease at time of presentation carry a worse prognosis. Level of Evidence: N/A.

AB - Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P =.632). Five-, 10-, and 20-year DSS rates were 81.3% (n = 117), 69.6% (n = 94), and 55.3% (n = 68), respectively. Men (hazard ratio, 4.74; P =.0087) and patients with regional (hazard ratio, 5.59; P =.018) or distant (hazard ratio, 8.9; P =.01) metastases carried a worse prognosis. Five-year DSS was greater in patients with localized disease (96.36%, P <.0001) than those with regional or distant metastases. Treatment with surgery alone had better 10-year DSS (86.3%) compared with treatment with combination radiation and surgery (57.6%) or radiation monotherapy (18.75%, P <.0001). Conclusions: Salivary clear cell carcinoma carries an overall good prognosis. Patients with localized disease and those treated with surgery alone have more favorable prognoses. Male patients and those with regional or distant metastatic disease at time of presentation carry a worse prognosis. Level of Evidence: N/A.

KW - End Results

KW - Epidemiology

KW - Surveillance

KW - disease-specific survival

KW - hyalinizing clear cell carcinoma

KW - population-based

KW - salivary clear cell carcinoma

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U2 - 10.1177/0003489419853597

DO - 10.1177/0003489419853597

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JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

ER -