TY - JOUR
T1 - SAMP1/YitFc mouse strain
T2 - A spontaneous model of Crohn's disease-like ileitis
AU - Pizarro, Theresa T.
AU - Pastorelli, Luca
AU - Bamias, Giorgos
AU - Garg, Rekha R.
AU - Reuter, Brian K.
AU - Mercado, Joseph R.
AU - Chieppa, Marcello
AU - Arseneau, Kristen O.
AU - Ley, Klaus
AU - Cominelli, Fabio
PY - 2011/12
Y1 - 2011/12
N2 - The SAMP1/YitFc mouse strain represents a model of Crohn's disease (CD)-like ileitis that is ideal for investigating the pathogenesis of chronic intestinal inflammation. Different from the vast majority of animal models of colitis, the ileal-specific phenotype characteristic of SAMP1/YitFc mice occurs spontaneously, without genetic, chemical, or immunological manipulation. In addition, SAMP1/YitFc mice possess remarkable similarities to the human condition with regard to disease location, histologic features, incidence of extraintestinal manifestations, and response to conventional therapies. SAMP1/YitFc mice also display a well-defined time course of a predisease state and phases of acute and chronic ileitis. As such, the SAMP1/YitFc model is particularly suitable for elucidating pathways that precede the clinical phenotype that may lead to preventive, and therefore more efficacious, intervention with the natural course of disease, or alternatively, for the development of therapeutic strategies directed against chronic, established ileitis. In this review we summarize important contributions made by our group and others that uncover potential mechanisms in the pathogenesis of CD using this unique murine model of chronic intestinal inflammation.
AB - The SAMP1/YitFc mouse strain represents a model of Crohn's disease (CD)-like ileitis that is ideal for investigating the pathogenesis of chronic intestinal inflammation. Different from the vast majority of animal models of colitis, the ileal-specific phenotype characteristic of SAMP1/YitFc mice occurs spontaneously, without genetic, chemical, or immunological manipulation. In addition, SAMP1/YitFc mice possess remarkable similarities to the human condition with regard to disease location, histologic features, incidence of extraintestinal manifestations, and response to conventional therapies. SAMP1/YitFc mice also display a well-defined time course of a predisease state and phases of acute and chronic ileitis. As such, the SAMP1/YitFc model is particularly suitable for elucidating pathways that precede the clinical phenotype that may lead to preventive, and therefore more efficacious, intervention with the natural course of disease, or alternatively, for the development of therapeutic strategies directed against chronic, established ileitis. In this review we summarize important contributions made by our group and others that uncover potential mechanisms in the pathogenesis of CD using this unique murine model of chronic intestinal inflammation.
KW - Crohn's disease
KW - adhesion molecules
KW - cytokines
KW - epithelial barrier function
KW - genetics
KW - intestinal microflora
KW - leukocyte trafficking
KW - spontaneous animal model of IBD
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UR - http://www.scopus.com/inward/citedby.url?scp=80054861647&partnerID=8YFLogxK
U2 - 10.1002/ibd.21638
DO - 10.1002/ibd.21638
M3 - Review article
C2 - 21557393
AN - SCOPUS:80054861647
SN - 1078-0998
VL - 17
SP - 2566
EP - 2584
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
IS - 12
ER -