Scalp EEG does not predict hemispherectomy outcome

Hansel M. Greiner, Yong D Park, Katherine Holland, Paul S. Horn, Anna W. Byars, Francesco T. Mangano, Joseph R. Smith, Mark R. Lee, Ki Hyeong Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Functional hemispherectomy is effective in carefully selected patients, resulting in a reduction of seizure burden up to complete resolution, improvement of intellectual development, and developmental benefit despite possible additional neurological deficit. Despite apparent hemispheric pathology on brain magnetic resonance imaging (MRI) or other imaging tests, scalp electroencephalography (EEG) could be suggestive of bilateral ictal onset or even ictal onset contralateral to the dominant imaging abnormality. We aimed to investigate the role of scalp EEG lateralization pre-operatively in predicting outcome. Methods: We retrospectively reviewed 54 patients who underwent hemispherectomy between 1991 and 2009 at Medical College of Georgia (1991-2006) and Cincinnati Children's Hospital Medical Center (2006-2009) and had at least one year post-operative follow-up. All preoperative EEGs were reviewed, and classified as either lateralizing or nonlateralizing, for both ictal and interictal EEG recordings. Results: Of 54 patients, 42 (78%) became seizure free. Twenty-four (44%) of 54 had a nonlateralizing ictal or interictal EEG. Further analysis was based on etiology of epilepsy, including malformation of cortical development (MCD), Rasmussen syndrome (RS), and stroke (CVA). EEG nonlateralization did not predict poor outcome in any of the etiology groups evaluated. Conclusion: Scalp EEG abnormalities in contralateral or bilateral hemispheres do not, in isolation, predict a poor outcome from hemispherectomy. Results of other non-invasive and invasive evaluations should be used to determine candidacy.

Original languageEnglish (US)
Pages (from-to)758-763
Number of pages6
JournalSeizure
Volume20
Issue number10
DOIs
StatePublished - Dec 1 2011

Fingerprint

Hemispherectomy
Scalp
Electroencephalography
Stroke
Seizures
Malformations of Cortical Development
Encephalitis
Epilepsy
Magnetic Resonance Imaging
Pathology
Brain

Keywords

  • Bilateral
  • EEG
  • Hemispherectomy
  • Hemispherotomy
  • Outcome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Greiner, H. M., Park, Y. D., Holland, K., Horn, P. S., Byars, A. W., Mangano, F. T., ... Lee, K. H. (2011). Scalp EEG does not predict hemispherectomy outcome. Seizure, 20(10), 758-763. https://doi.org/10.1016/j.seizure.2011.07.006

Scalp EEG does not predict hemispherectomy outcome. / Greiner, Hansel M.; Park, Yong D; Holland, Katherine; Horn, Paul S.; Byars, Anna W.; Mangano, Francesco T.; Smith, Joseph R.; Lee, Mark R.; Lee, Ki Hyeong.

In: Seizure, Vol. 20, No. 10, 01.12.2011, p. 758-763.

Research output: Contribution to journalArticle

Greiner, HM, Park, YD, Holland, K, Horn, PS, Byars, AW, Mangano, FT, Smith, JR, Lee, MR & Lee, KH 2011, 'Scalp EEG does not predict hemispherectomy outcome', Seizure, vol. 20, no. 10, pp. 758-763. https://doi.org/10.1016/j.seizure.2011.07.006
Greiner HM, Park YD, Holland K, Horn PS, Byars AW, Mangano FT et al. Scalp EEG does not predict hemispherectomy outcome. Seizure. 2011 Dec 1;20(10):758-763. https://doi.org/10.1016/j.seizure.2011.07.006
Greiner, Hansel M. ; Park, Yong D ; Holland, Katherine ; Horn, Paul S. ; Byars, Anna W. ; Mangano, Francesco T. ; Smith, Joseph R. ; Lee, Mark R. ; Lee, Ki Hyeong. / Scalp EEG does not predict hemispherectomy outcome. In: Seizure. 2011 ; Vol. 20, No. 10. pp. 758-763.
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