SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients

Min Tao; Biaoru Li; Jaya Nayini; Colleen B. Andrews; Ray Win Huang; Emmanuelle Devemy; Shiwen Song; Parameswaran Venugopal; Harvey D. Preisler

doi:10.1006/cyto.2000.0666

SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients

Min Tao, Biaoru Li, Jaya Nayini, Colleen B. Andrews, Ray Win Huang, Emmanuelle Devemy, Shiwen Song, Parameswaran Venugopal, Harvey D. Preisler

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

This study compared cytokine transcript and protein levels in BM cells of normal individuals and leukemic patients. AML differed from normal in that: (1) AML marrow cells contain more IL-1β protein than normal cells, (2) IL-1ra transcripts are absent from AML marrow cells, (3) AML marrow serum contains less IL-1ra protein than normal, (4) peripheral blood and marrow serum of AML patients contains more SCF protein than normal serum, and (5) SCF transcripts have been detected in AML marrow biopsies and not in aspirate cells. These data suggest that unbalanced cytokine production may make a significant contribution to the abnormal behaviour of AML cells. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	699-707
Number of pages	9
Journal	Cytokine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1006/cyto.2000.0666
State	Published - Jun 2000
Externally published	Yes

Keywords

Leukemia
Marrow cytokines
Serum cytokines

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

Access to Document

10.1006/cyto.2000.0666

Cite this

@article{c09037413d6943c1afd2bcc43d77deec,

title = "SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients",

abstract = "This study compared cytokine transcript and protein levels in BM cells of normal individuals and leukemic patients. AML differed from normal in that: (1) AML marrow cells contain more IL-1β protein than normal cells, (2) IL-1ra transcripts are absent from AML marrow cells, (3) AML marrow serum contains less IL-1ra protein than normal, (4) peripheral blood and marrow serum of AML patients contains more SCF protein than normal serum, and (5) SCF transcripts have been detected in AML marrow biopsies and not in aspirate cells. These data suggest that unbalanced cytokine production may make a significant contribution to the abnormal behaviour of AML cells. (C) 2000 Academic Press.",

keywords = "Leukemia, Marrow cytokines, Serum cytokines",

author = "Min Tao and Biaoru Li and Jaya Nayini and Andrews, {Colleen B.} and Huang, {Ray Win} and Emmanuelle Devemy and Shiwen Song and Parameswaran Venugopal and Preisler, {Harvey D.}",

note = "Funding Information: This work was supported by the National Cancer Institute grant 1-PO-1 CA75606-03.",

year = "2000",

month = jun,

doi = "10.1006/cyto.2000.0666",

language = "English (US)",

volume = "12",

pages = "699--707",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press Inc.",

number = "6",

}

TY - JOUR

T1 - SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients

AU - Tao, Min

AU - Li, Biaoru

AU - Nayini, Jaya

AU - Andrews, Colleen B.

AU - Huang, Ray Win

AU - Devemy, Emmanuelle

AU - Song, Shiwen

AU - Venugopal, Parameswaran

AU - Preisler, Harvey D.

N1 - Funding Information: This work was supported by the National Cancer Institute grant 1-PO-1 CA75606-03.

PY - 2000/6

Y1 - 2000/6

N2 - This study compared cytokine transcript and protein levels in BM cells of normal individuals and leukemic patients. AML differed from normal in that: (1) AML marrow cells contain more IL-1β protein than normal cells, (2) IL-1ra transcripts are absent from AML marrow cells, (3) AML marrow serum contains less IL-1ra protein than normal, (4) peripheral blood and marrow serum of AML patients contains more SCF protein than normal serum, and (5) SCF transcripts have been detected in AML marrow biopsies and not in aspirate cells. These data suggest that unbalanced cytokine production may make a significant contribution to the abnormal behaviour of AML cells. (C) 2000 Academic Press.

AB - This study compared cytokine transcript and protein levels in BM cells of normal individuals and leukemic patients. AML differed from normal in that: (1) AML marrow cells contain more IL-1β protein than normal cells, (2) IL-1ra transcripts are absent from AML marrow cells, (3) AML marrow serum contains less IL-1ra protein than normal, (4) peripheral blood and marrow serum of AML patients contains more SCF protein than normal serum, and (5) SCF transcripts have been detected in AML marrow biopsies and not in aspirate cells. These data suggest that unbalanced cytokine production may make a significant contribution to the abnormal behaviour of AML cells. (C) 2000 Academic Press.

KW - Leukemia

KW - Marrow cytokines

KW - Serum cytokines

UR - http://www.scopus.com/inward/record.url?scp=0033625335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033625335&partnerID=8YFLogxK

U2 - 10.1006/cyto.2000.0666

DO - 10.1006/cyto.2000.0666

M3 - Article

C2 - 10843748

AN - SCOPUS:0033625335

SN - 1043-4666

VL - 12

SP - 699

EP - 707

JO - Cytokine

JF - Cytokine

IS - 6

ER -

SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this