SCF, IL-1β, IL-1ra and GM-CSF in the bone marrow and serum of normal individuals and of AML and CML in patients

Min Tao, Biaoru Li, Jaya Nayini, Colleen B. Andrews, Ray Win Huang, Emmanuelle Devemy, Shiwen Song, Parameswaran Venugopal, Harvey D. Preisler

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

This study compared cytokine transcript and protein levels in BM cells of normal individuals and leukemic patients. AML differed from normal in that: (1) AML marrow cells contain more IL-1β protein than normal cells, (2) IL-1ra transcripts are absent from AML marrow cells, (3) AML marrow serum contains less IL-1ra protein than normal, (4) peripheral blood and marrow serum of AML patients contains more SCF protein than normal serum, and (5) SCF transcripts have been detected in AML marrow biopsies and not in aspirate cells. These data suggest that unbalanced cytokine production may make a significant contribution to the abnormal behaviour of AML cells. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalCytokine
Volume12
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

Keywords

  • Leukemia
  • Marrow cytokines
  • Serum cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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