Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker

Jeffrey Bedwell, L. Miller, James Brown, Nathan Yanasak

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.

Original languageEnglish (US)
Pages (from-to)881-894
Number of pages14
JournalInternational Journal of Neuroscience
Volume116
Issue number8
DOIs
StatePublished - Aug 1 2006

Keywords

  • Biobehavioral marker
  • Endophenotype
  • First-degree relatives
  • Functional magnetic resonance imaging
  • Magnocellular visual pathway
  • Red light

ASJC Scopus subject areas

  • Neuroscience(all)

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