Abstract
Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 881-894 |
| Number of pages | 14 |
| Journal | International Journal of Neuroscience |
| Volume | 116 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2006 |
Keywords
- Biobehavioral marker
- Endophenotype
- First-degree relatives
- Functional magnetic resonance imaging
- Magnocellular visual pathway
- Red light
ASJC Scopus subject areas
- Neuroscience(all)
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Bedwell, J., Miller, L., Brown, J., & Yanasak, N. (2006). Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker. International Journal of Neuroscience, 116(8), 881-894. https://doi.org/10.1080/00207450500516529