TY - JOUR
T1 - Schizophrenia and red light
T2 - fMRI evidence for a novel biobehavioral marker
AU - Bedwell, Jeffrey
AU - Miller, L.
AU - Brown, James
AU - Yanasak, Nathan
N1 - Funding Information:
Funding for this study was provided to JSB by the American Psychological Foundation (Manfred Meier Neuropsychology Scholarship) and to LSM by the University of Georgia Research Foundation. Special thanks to Yfat Kessel, B.A. for help with data collection and to Sharon Esposito, M.D. and Advantage Behavioral Health Systems (Athens, GA) for help in recruiting the relatives.
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
AB - Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
KW - Biobehavioral marker
KW - Endophenotype
KW - First-degree relatives
KW - Functional magnetic resonance imaging
KW - Magnocellular visual pathway
KW - Red light
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U2 - 10.1080/00207450500516529
DO - 10.1080/00207450500516529
M3 - Article
C2 - 16861153
AN - SCOPUS:33746599911
SN - 0020-7454
VL - 116
SP - 881
EP - 894
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 8
ER -