Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker

Jeffrey Bedwell; L. Miller; James Brown; Nathan Yanasak

doi:10.1080/00207450500516529

Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker

Jeffrey Bedwell, L. Miller, James Brown, Nathan Yanasak

Radiology and Imaging

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.

Original language	English (US)
Pages (from-to)	881-894
Number of pages	14
Journal	International Journal of Neuroscience
Volume	116
Issue number	8
DOIs	https://doi.org/10.1080/00207450500516529
State	Published - Aug 1 2006

Keywords

Biobehavioral marker
Endophenotype
First-degree relatives
Functional magnetic resonance imaging
Magnocellular visual pathway
Red light

ASJC Scopus subject areas

Neuroscience(all)

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10.1080/00207450500516529

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abstract = "Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.",

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