Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker

Jeffrey Bedwell, L. Miller, James Brown, Nathan Yanasak

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.

Original languageEnglish (US)
Pages (from-to)881-894
Number of pages14
JournalInternational Journal of Neuroscience
Volume116
Issue number8
DOIs
StatePublished - Aug 1 2006

Keywords

  • Biobehavioral marker
  • Endophenotype
  • First-degree relatives
  • Functional magnetic resonance imaging
  • Magnocellular visual pathway
  • Red light

ASJC Scopus subject areas

  • Neuroscience(all)

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