Abstract
Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 881-894 |
| Number of pages | 14 |
| Journal | International Journal of Neuroscience |
| Volume | 116 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2006 |
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Keywords
- Biobehavioral marker
- Endophenotype
- First-degree relatives
- Functional magnetic resonance imaging
- Magnocellular visual pathway
- Red light
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Schizophrenia and red light : fMRI evidence for a novel biobehavioral marker. / Bedwell, Jeffrey; Miller, L.; Brown, James; Yanasak, Nathan.
In: International Journal of Neuroscience, Vol. 116, No. 8, 01.08.2006, p. 881-894.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Schizophrenia and red light
T2 - fMRI evidence for a novel biobehavioral marker
AU - Bedwell, Jeffrey
AU - Miller, L.
AU - Brown, James
AU - Yanasak, Nathan
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
AB - Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
KW - Biobehavioral marker
KW - Endophenotype
KW - First-degree relatives
KW - Functional magnetic resonance imaging
KW - Magnocellular visual pathway
KW - Red light
UR - http://www.scopus.com/inward/record.url?scp=33746599911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746599911&partnerID=8YFLogxK
U2 - 10.1080/00207450500516529
DO - 10.1080/00207450500516529
M3 - Article
C2 - 16861153
AN - SCOPUS:33746599911
VL - 116
SP - 881
EP - 894
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
SN - 0020-7454
IS - 8
ER -