Scopolamine facilitates recovery of function following unilateral electrolytic sensorimotor cortex lesions in the rat

R. M. Saponjic, Michael R. Hoane, S. Barbay, T. M. Barth

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Following brain injury there is an excessive release of excitatory neurotransmitters that may lead to secondary cell death. Although much research has focused on glutamate-NMDA receptor interactions, acetylcholine-muscarinic receptor interactions may also prove to be important for an understanding of the pathophysiological events that lead to secondary degeneration after brain damage. Previous experiments have shown that the muscarinic receptor antagonist scopolamine facilitates recovery from very transient (1 h—10 days) behavioral deficits after fluid percussion injury. The present study extends these findings by investigating whether scopolamine can facilitate recovery from the more enduring behavioral deficits (14–60 days) that follow electrolytic lesions of the rat somatic sensorimotor cortex (SMC). Rats received unilateral lesions of the SMC and a regimen of scopolamine (1 mg/kg) or saline beginning 15 min after surgery. Following SMC lesions rats exhibited an impairment in placing the forelimb contralateral to the lesion as well as an ipsilateral somatosensory asymmetry on a bilateral tactile stimulation test. Rats treated with scopolamine showed a reduction in the initial magnitude of the contralateral placing deficit and an accelerated rate of recovery compared with saline-treated control rats. In contrast, scopolamine had no effect on recovery from the ipsilateral somatosensory asymmetry. These data are consistent with the idea that muscarinic receptor stimulation plays a role in the production of secondary brain damage, that blockade of this receptor leads to a facilitation of recovery on some behavioral tasks, and that electrolytic lesions may trigger some of the same posttraumatic events described in other models of neural trauma.

Original languageEnglish (US)
Pages (from-to)205-212
Number of pages8
JournalRestorative Neurology and Neuroscience
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1995

Fingerprint

Scopolamine Hydrobromide
Recovery of Function
Muscarinic Receptors
Percussion
Muscarinic Antagonists
Forelimb
Wounds and Injuries
Glutamate Receptors
Brain
Touch
N-Methyl-D-Aspartate Receptors
Brain Injuries
Neurotransmitter Agents
Cell Death
Sensorimotor Cortex
Research

Keywords

  • Acetylcholine
  • Forelimb-placing
  • Muscarinic receptor
  • Secondary brain damage

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Scopolamine facilitates recovery of function following unilateral electrolytic sensorimotor cortex lesions in the rat. / Saponjic, R. M.; Hoane, Michael R.; Barbay, S.; Barth, T. M.

In: Restorative Neurology and Neuroscience, Vol. 8, No. 4, 01.01.1995, p. 205-212.

Research output: Contribution to journalArticle

@article{38276bcd7a6446bb97cdede994bf5ccf,
title = "Scopolamine facilitates recovery of function following unilateral electrolytic sensorimotor cortex lesions in the rat",
abstract = "Following brain injury there is an excessive release of excitatory neurotransmitters that may lead to secondary cell death. Although much research has focused on glutamate-NMDA receptor interactions, acetylcholine-muscarinic receptor interactions may also prove to be important for an understanding of the pathophysiological events that lead to secondary degeneration after brain damage. Previous experiments have shown that the muscarinic receptor antagonist scopolamine facilitates recovery from very transient (1 h—10 days) behavioral deficits after fluid percussion injury. The present study extends these findings by investigating whether scopolamine can facilitate recovery from the more enduring behavioral deficits (14–60 days) that follow electrolytic lesions of the rat somatic sensorimotor cortex (SMC). Rats received unilateral lesions of the SMC and a regimen of scopolamine (1 mg/kg) or saline beginning 15 min after surgery. Following SMC lesions rats exhibited an impairment in placing the forelimb contralateral to the lesion as well as an ipsilateral somatosensory asymmetry on a bilateral tactile stimulation test. Rats treated with scopolamine showed a reduction in the initial magnitude of the contralateral placing deficit and an accelerated rate of recovery compared with saline-treated control rats. In contrast, scopolamine had no effect on recovery from the ipsilateral somatosensory asymmetry. These data are consistent with the idea that muscarinic receptor stimulation plays a role in the production of secondary brain damage, that blockade of this receptor leads to a facilitation of recovery on some behavioral tasks, and that electrolytic lesions may trigger some of the same posttraumatic events described in other models of neural trauma.",
keywords = "Acetylcholine, Forelimb-placing, Muscarinic receptor, Secondary brain damage",
author = "Saponjic, {R. M.} and Hoane, {Michael R.} and S. Barbay and Barth, {T. M.}",
year = "1995",
month = "1",
day = "1",
doi = "10.3233/RNN-1995-8406",
language = "English (US)",
volume = "8",
pages = "205--212",
journal = "Restorative Neurology and Neuroscience",
issn = "0922-6028",
publisher = "IOS Press",
number = "4",

}

TY - JOUR

T1 - Scopolamine facilitates recovery of function following unilateral electrolytic sensorimotor cortex lesions in the rat

AU - Saponjic, R. M.

AU - Hoane, Michael R.

AU - Barbay, S.

AU - Barth, T. M.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Following brain injury there is an excessive release of excitatory neurotransmitters that may lead to secondary cell death. Although much research has focused on glutamate-NMDA receptor interactions, acetylcholine-muscarinic receptor interactions may also prove to be important for an understanding of the pathophysiological events that lead to secondary degeneration after brain damage. Previous experiments have shown that the muscarinic receptor antagonist scopolamine facilitates recovery from very transient (1 h—10 days) behavioral deficits after fluid percussion injury. The present study extends these findings by investigating whether scopolamine can facilitate recovery from the more enduring behavioral deficits (14–60 days) that follow electrolytic lesions of the rat somatic sensorimotor cortex (SMC). Rats received unilateral lesions of the SMC and a regimen of scopolamine (1 mg/kg) or saline beginning 15 min after surgery. Following SMC lesions rats exhibited an impairment in placing the forelimb contralateral to the lesion as well as an ipsilateral somatosensory asymmetry on a bilateral tactile stimulation test. Rats treated with scopolamine showed a reduction in the initial magnitude of the contralateral placing deficit and an accelerated rate of recovery compared with saline-treated control rats. In contrast, scopolamine had no effect on recovery from the ipsilateral somatosensory asymmetry. These data are consistent with the idea that muscarinic receptor stimulation plays a role in the production of secondary brain damage, that blockade of this receptor leads to a facilitation of recovery on some behavioral tasks, and that electrolytic lesions may trigger some of the same posttraumatic events described in other models of neural trauma.

AB - Following brain injury there is an excessive release of excitatory neurotransmitters that may lead to secondary cell death. Although much research has focused on glutamate-NMDA receptor interactions, acetylcholine-muscarinic receptor interactions may also prove to be important for an understanding of the pathophysiological events that lead to secondary degeneration after brain damage. Previous experiments have shown that the muscarinic receptor antagonist scopolamine facilitates recovery from very transient (1 h—10 days) behavioral deficits after fluid percussion injury. The present study extends these findings by investigating whether scopolamine can facilitate recovery from the more enduring behavioral deficits (14–60 days) that follow electrolytic lesions of the rat somatic sensorimotor cortex (SMC). Rats received unilateral lesions of the SMC and a regimen of scopolamine (1 mg/kg) or saline beginning 15 min after surgery. Following SMC lesions rats exhibited an impairment in placing the forelimb contralateral to the lesion as well as an ipsilateral somatosensory asymmetry on a bilateral tactile stimulation test. Rats treated with scopolamine showed a reduction in the initial magnitude of the contralateral placing deficit and an accelerated rate of recovery compared with saline-treated control rats. In contrast, scopolamine had no effect on recovery from the ipsilateral somatosensory asymmetry. These data are consistent with the idea that muscarinic receptor stimulation plays a role in the production of secondary brain damage, that blockade of this receptor leads to a facilitation of recovery on some behavioral tasks, and that electrolytic lesions may trigger some of the same posttraumatic events described in other models of neural trauma.

KW - Acetylcholine

KW - Forelimb-placing

KW - Muscarinic receptor

KW - Secondary brain damage

UR - http://www.scopus.com/inward/record.url?scp=0029091911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029091911&partnerID=8YFLogxK

U2 - 10.3233/RNN-1995-8406

DO - 10.3233/RNN-1995-8406

M3 - Article

VL - 8

SP - 205

EP - 212

JO - Restorative Neurology and Neuroscience

JF - Restorative Neurology and Neuroscience

SN - 0922-6028

IS - 4

ER -