Screening for chlamydia and gonorrhea cervicitis and implications for pregnancy outcome

Are we testing and treating at the right time?

Meghan G. Hill, Seema Menon, Sarah Smith, Hongmei Zhang, Xin Tong, Paul C. Browne

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the effect of gonorrheal and chlamydial cervicitis (GCC) on the risk of preterm labor (PTL) and preterm premature rupture of membranes (PPROM).

STUDY DESIGN: A large cross-sectional sample of patients (N = 1,120) was studied. Data on samples for GCC and pregnancy outcome were entered into a database from a retrospective chart review.

RESULTS: There were 1,120 pregnancies with adequate data for analysis. Of those pregnancies 933 were unaffected by GCC, and 187 were affected. The rates of preterm delivery were 17.79% and 16.58% for GCC-negative and GCC-positive pregnancies, respectively. PPROM occurred in 3.97% and 2.67% of GCC-negative and GCC-positive pregnancies, respectively. PTL occurred in 8.25% and 8.02% of GCC-negative and GCC-positive pregnancies, respectively. No outcomes met statistical significance. When pregnancy outcomes were analyzed by trimester of infection, there was a higher risk of preterm delivery but not preterm labor with earlier infection. This did meet statistical significance. There was a trend towards lower rate of cesarean section in the infected group of patients, which did not meet statistical significance.

CONCLUSION: Maternal infection with gonorrhea and/or chlamydia is not associated with PPROM or PTL.

Original languageEnglish (US)
Pages (from-to)301-308
Number of pages8
JournalThe Journal of reproductive medicine
Volume60
Issue number7-8
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Uterine Cervicitis
Chlamydia
Gonorrhea
Pregnancy Outcome
Premature Obstetric Labor
Pregnancy
Infection
Cesarean Section
Mothers
Databases

Keywords

  • Chlamydia
  • Chlamydia trachomatis
  • Gonorrhea
  • Preterm labor
  • Preterm premature rupture of membranes

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Screening for chlamydia and gonorrhea cervicitis and implications for pregnancy outcome : Are we testing and treating at the right time? / Hill, Meghan G.; Menon, Seema; Smith, Sarah; Zhang, Hongmei; Tong, Xin; Browne, Paul C.

In: The Journal of reproductive medicine, Vol. 60, No. 7-8, 01.07.2015, p. 301-308.

Research output: Contribution to journalArticle

Hill, Meghan G. ; Menon, Seema ; Smith, Sarah ; Zhang, Hongmei ; Tong, Xin ; Browne, Paul C. / Screening for chlamydia and gonorrhea cervicitis and implications for pregnancy outcome : Are we testing and treating at the right time?. In: The Journal of reproductive medicine. 2015 ; Vol. 60, No. 7-8. pp. 301-308.
@article{65c6ce36d4e8457ebcb6fd5644892a51,
title = "Screening for chlamydia and gonorrhea cervicitis and implications for pregnancy outcome: Are we testing and treating at the right time?",
abstract = "OBJECTIVE: To evaluate the effect of gonorrheal and chlamydial cervicitis (GCC) on the risk of preterm labor (PTL) and preterm premature rupture of membranes (PPROM).STUDY DESIGN: A large cross-sectional sample of patients (N = 1,120) was studied. Data on samples for GCC and pregnancy outcome were entered into a database from a retrospective chart review.RESULTS: There were 1,120 pregnancies with adequate data for analysis. Of those pregnancies 933 were unaffected by GCC, and 187 were affected. The rates of preterm delivery were 17.79{\%} and 16.58{\%} for GCC-negative and GCC-positive pregnancies, respectively. PPROM occurred in 3.97{\%} and 2.67{\%} of GCC-negative and GCC-positive pregnancies, respectively. PTL occurred in 8.25{\%} and 8.02{\%} of GCC-negative and GCC-positive pregnancies, respectively. No outcomes met statistical significance. When pregnancy outcomes were analyzed by trimester of infection, there was a higher risk of preterm delivery but not preterm labor with earlier infection. This did meet statistical significance. There was a trend towards lower rate of cesarean section in the infected group of patients, which did not meet statistical significance.CONCLUSION: Maternal infection with gonorrhea and/or chlamydia is not associated with PPROM or PTL.",
keywords = "Chlamydia, Chlamydia trachomatis, Gonorrhea, Preterm labor, Preterm premature rupture of membranes",
author = "Hill, {Meghan G.} and Seema Menon and Sarah Smith and Hongmei Zhang and Xin Tong and Browne, {Paul C.}",
year = "2015",
month = "7",
day = "1",
language = "English (US)",
volume = "60",
pages = "301--308",
journal = "Journal of Reproductive Medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "7-8",

}

TY - JOUR

T1 - Screening for chlamydia and gonorrhea cervicitis and implications for pregnancy outcome

T2 - Are we testing and treating at the right time?

AU - Hill, Meghan G.

AU - Menon, Seema

AU - Smith, Sarah

AU - Zhang, Hongmei

AU - Tong, Xin

AU - Browne, Paul C.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - OBJECTIVE: To evaluate the effect of gonorrheal and chlamydial cervicitis (GCC) on the risk of preterm labor (PTL) and preterm premature rupture of membranes (PPROM).STUDY DESIGN: A large cross-sectional sample of patients (N = 1,120) was studied. Data on samples for GCC and pregnancy outcome were entered into a database from a retrospective chart review.RESULTS: There were 1,120 pregnancies with adequate data for analysis. Of those pregnancies 933 were unaffected by GCC, and 187 were affected. The rates of preterm delivery were 17.79% and 16.58% for GCC-negative and GCC-positive pregnancies, respectively. PPROM occurred in 3.97% and 2.67% of GCC-negative and GCC-positive pregnancies, respectively. PTL occurred in 8.25% and 8.02% of GCC-negative and GCC-positive pregnancies, respectively. No outcomes met statistical significance. When pregnancy outcomes were analyzed by trimester of infection, there was a higher risk of preterm delivery but not preterm labor with earlier infection. This did meet statistical significance. There was a trend towards lower rate of cesarean section in the infected group of patients, which did not meet statistical significance.CONCLUSION: Maternal infection with gonorrhea and/or chlamydia is not associated with PPROM or PTL.

AB - OBJECTIVE: To evaluate the effect of gonorrheal and chlamydial cervicitis (GCC) on the risk of preterm labor (PTL) and preterm premature rupture of membranes (PPROM).STUDY DESIGN: A large cross-sectional sample of patients (N = 1,120) was studied. Data on samples for GCC and pregnancy outcome were entered into a database from a retrospective chart review.RESULTS: There were 1,120 pregnancies with adequate data for analysis. Of those pregnancies 933 were unaffected by GCC, and 187 were affected. The rates of preterm delivery were 17.79% and 16.58% for GCC-negative and GCC-positive pregnancies, respectively. PPROM occurred in 3.97% and 2.67% of GCC-negative and GCC-positive pregnancies, respectively. PTL occurred in 8.25% and 8.02% of GCC-negative and GCC-positive pregnancies, respectively. No outcomes met statistical significance. When pregnancy outcomes were analyzed by trimester of infection, there was a higher risk of preterm delivery but not preterm labor with earlier infection. This did meet statistical significance. There was a trend towards lower rate of cesarean section in the infected group of patients, which did not meet statistical significance.CONCLUSION: Maternal infection with gonorrhea and/or chlamydia is not associated with PPROM or PTL.

KW - Chlamydia

KW - Chlamydia trachomatis

KW - Gonorrhea

KW - Preterm labor

KW - Preterm premature rupture of membranes

UR - http://www.scopus.com/inward/record.url?scp=84946234622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946234622&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 301

EP - 308

JO - Journal of Reproductive Medicine

JF - Journal of Reproductive Medicine

SN - 0024-7758

IS - 7-8

ER -