Searching for the mechanism(s) of ECT's therapeutic effect

William Vaughn McCall, Chittaranjan Andrade, Pascal Sienaert

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The exact therapeutic mechanism of action of electroconvulsive therapy (ECT) remains unresolved. Numerous psychological theories from decades ago have been proven untrue. In the ensuing years, ECT has been proven to have numerous reproducible effects on brain chemistry, regional brain activity, electroencephalographic sleep stages, and neurogenesis. Clinically, ECT has been shown to have antidepressant, antipsychotic, antimanic, antiparkinsonian, and anticonvulsive effects. It is possible that different biological effects of ECT are responsible for different clinical effects or that several biological effects in concert work together to produce a given clinical effect. This paper comments on the array of possible mechanisms and points toward the future of mechanistic research in ECT.

Original languageEnglish (US)
Pages (from-to)87-89
Number of pages3
JournalJournal of ECT
Volume30
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Electroconvulsive Therapy
Therapeutic Uses
Brain Chemistry
Antimanic Agents
Psychological Theory
Antiparkinson Agents
Sleep Stages
Neurogenesis
Antidepressive Agents
Antipsychotic Agents
Brain
Research

Keywords

  • ECT
  • Mechanism

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Psychiatry and Mental health

Cite this

Searching for the mechanism(s) of ECT's therapeutic effect. / McCall, William Vaughn; Andrade, Chittaranjan; Sienaert, Pascal.

In: Journal of ECT, Vol. 30, No. 2, 01.01.2014, p. 87-89.

Research output: Contribution to journalReview article

McCall, William Vaughn ; Andrade, Chittaranjan ; Sienaert, Pascal. / Searching for the mechanism(s) of ECT's therapeutic effect. In: Journal of ECT. 2014 ; Vol. 30, No. 2. pp. 87-89.
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