Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure

Stephen P. Laguardia, Brian K. Dockery, Syamal K. Bhattacharya, Maeda D. Nelson, Laura D Carbone, Karl T. Weber

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: We previously noted secondary hyperparathyroidism (SHPT) in African-American patients hospitalized during February, 2005 with either untreated or treated congestive heart failure (CHF) due to ischemic or idiopathic cardiomyopathy. Herein, we hypothesized that housebound African-American patients hospitalized during the period of June 1 through August 31, 2005, with CHF would have SHPT and hypovitaminosis D. METHODS: Twenty-five African-American patients with an ejection fraction (EF) less than 35% due to ischemic or dilated (idiopathic) cardiomyopathy were monitored: 20 were hospitalized with CHF, stratified on historical grounds as of 4 weeks' or longer duration or of 1 to 2 weeks' duration in 11 and 9 patients, respectively, despite medical care that included furosemide; serum parathyroid hormone (PTH) and 25(OH)D at the time of admission in these patients were compared to five asymptomatic outpatients seen during the summer with stable, compensated failure. RESULTS: Serum PTH was elevated (127 ± 13; 82-243 pg/mL) in all patients with CHF of 4 weeks' or longer duration (normal, 12-65 pg/mL) and was elevated in three of nine patients (59 ± 8; 18-99 pg/mL) with CHF of 1 to 2 weeks' duration. Ionized hypocalcemia (1.09 ± 0.03 and 1.08 ± 0.02 mmol/L; normal, 1.12-1.30) and hypomagnesemia (0.47 ± 0.02 and 0.46 ± 0.03 mmol/L; normal, 0.53-0.67) were respectively found in long- or short-duration CHF. No compensated patient had elevated PTH (42 ± 5; 17-53). Hypovitaminosis D (≤30 ng/mL) was universally present in patients with CHF of 4 weeks' or longer duration (15.1 ± 1.4; 7.0-23.8 ng/mL) and was also prevalent in the other groups (20.3 ± 5.1, 7.0-54.1 ng/mL in CHF of 1 to 2 weeks' duration and 23.1 ± 4.9; 17.2-42.7 ng/mL in compensated failure). CONCLUSIONS: In African-American patients with CHF, hypovitaminosis D, aldosteronism, and loop diuretic treatment each exaggerate Ca and Mg losses to stress a fragile Ca balance leading to ionized hypocalcemia and hypomagnesemia with SHPT.

Original languageEnglish (US)
Pages (from-to)112-118
Number of pages7
JournalAmerican Journal of the Medical Sciences
Volume332
Issue number3
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Secondary Hyperparathyroidism
African Americans
Heart Failure
Parathyroid Hormone
Hypocalcemia
Sodium Potassium Chloride Symporter Inhibitors
Hyperaldosteronism
Patient Admission
Furosemide
Dilated Cardiomyopathy
Serum
Cardiomyopathies
Outpatients

Keywords

  • African-Americans
  • Congestive heart failure
  • Ionized hypocalcemia
  • Ionized hypomagnesemia
  • Parathyroid hormone
  • Vitamin D

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure. / Laguardia, Stephen P.; Dockery, Brian K.; Bhattacharya, Syamal K.; Nelson, Maeda D.; Carbone, Laura D; Weber, Karl T.

In: American Journal of the Medical Sciences, Vol. 332, No. 3, 01.01.2006, p. 112-118.

Research output: Contribution to journalArticle

Laguardia, Stephen P. ; Dockery, Brian K. ; Bhattacharya, Syamal K. ; Nelson, Maeda D. ; Carbone, Laura D ; Weber, Karl T. / Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure. In: American Journal of the Medical Sciences. 2006 ; Vol. 332, No. 3. pp. 112-118.
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T1 - Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure

AU - Laguardia, Stephen P.

AU - Dockery, Brian K.

AU - Bhattacharya, Syamal K.

AU - Nelson, Maeda D.

AU - Carbone, Laura D

AU - Weber, Karl T.

PY - 2006/1/1

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N2 - OBJECTIVE: We previously noted secondary hyperparathyroidism (SHPT) in African-American patients hospitalized during February, 2005 with either untreated or treated congestive heart failure (CHF) due to ischemic or idiopathic cardiomyopathy. Herein, we hypothesized that housebound African-American patients hospitalized during the period of June 1 through August 31, 2005, with CHF would have SHPT and hypovitaminosis D. METHODS: Twenty-five African-American patients with an ejection fraction (EF) less than 35% due to ischemic or dilated (idiopathic) cardiomyopathy were monitored: 20 were hospitalized with CHF, stratified on historical grounds as of 4 weeks' or longer duration or of 1 to 2 weeks' duration in 11 and 9 patients, respectively, despite medical care that included furosemide; serum parathyroid hormone (PTH) and 25(OH)D at the time of admission in these patients were compared to five asymptomatic outpatients seen during the summer with stable, compensated failure. RESULTS: Serum PTH was elevated (127 ± 13; 82-243 pg/mL) in all patients with CHF of 4 weeks' or longer duration (normal, 12-65 pg/mL) and was elevated in three of nine patients (59 ± 8; 18-99 pg/mL) with CHF of 1 to 2 weeks' duration. Ionized hypocalcemia (1.09 ± 0.03 and 1.08 ± 0.02 mmol/L; normal, 1.12-1.30) and hypomagnesemia (0.47 ± 0.02 and 0.46 ± 0.03 mmol/L; normal, 0.53-0.67) were respectively found in long- or short-duration CHF. No compensated patient had elevated PTH (42 ± 5; 17-53). Hypovitaminosis D (≤30 ng/mL) was universally present in patients with CHF of 4 weeks' or longer duration (15.1 ± 1.4; 7.0-23.8 ng/mL) and was also prevalent in the other groups (20.3 ± 5.1, 7.0-54.1 ng/mL in CHF of 1 to 2 weeks' duration and 23.1 ± 4.9; 17.2-42.7 ng/mL in compensated failure). CONCLUSIONS: In African-American patients with CHF, hypovitaminosis D, aldosteronism, and loop diuretic treatment each exaggerate Ca and Mg losses to stress a fragile Ca balance leading to ionized hypocalcemia and hypomagnesemia with SHPT.

AB - OBJECTIVE: We previously noted secondary hyperparathyroidism (SHPT) in African-American patients hospitalized during February, 2005 with either untreated or treated congestive heart failure (CHF) due to ischemic or idiopathic cardiomyopathy. Herein, we hypothesized that housebound African-American patients hospitalized during the period of June 1 through August 31, 2005, with CHF would have SHPT and hypovitaminosis D. METHODS: Twenty-five African-American patients with an ejection fraction (EF) less than 35% due to ischemic or dilated (idiopathic) cardiomyopathy were monitored: 20 were hospitalized with CHF, stratified on historical grounds as of 4 weeks' or longer duration or of 1 to 2 weeks' duration in 11 and 9 patients, respectively, despite medical care that included furosemide; serum parathyroid hormone (PTH) and 25(OH)D at the time of admission in these patients were compared to five asymptomatic outpatients seen during the summer with stable, compensated failure. RESULTS: Serum PTH was elevated (127 ± 13; 82-243 pg/mL) in all patients with CHF of 4 weeks' or longer duration (normal, 12-65 pg/mL) and was elevated in three of nine patients (59 ± 8; 18-99 pg/mL) with CHF of 1 to 2 weeks' duration. Ionized hypocalcemia (1.09 ± 0.03 and 1.08 ± 0.02 mmol/L; normal, 1.12-1.30) and hypomagnesemia (0.47 ± 0.02 and 0.46 ± 0.03 mmol/L; normal, 0.53-0.67) were respectively found in long- or short-duration CHF. No compensated patient had elevated PTH (42 ± 5; 17-53). Hypovitaminosis D (≤30 ng/mL) was universally present in patients with CHF of 4 weeks' or longer duration (15.1 ± 1.4; 7.0-23.8 ng/mL) and was also prevalent in the other groups (20.3 ± 5.1, 7.0-54.1 ng/mL in CHF of 1 to 2 weeks' duration and 23.1 ± 4.9; 17.2-42.7 ng/mL in compensated failure). CONCLUSIONS: In African-American patients with CHF, hypovitaminosis D, aldosteronism, and loop diuretic treatment each exaggerate Ca and Mg losses to stress a fragile Ca balance leading to ionized hypocalcemia and hypomagnesemia with SHPT.

KW - African-Americans

KW - Congestive heart failure

KW - Ionized hypocalcemia

KW - Ionized hypomagnesemia

KW - Parathyroid hormone

KW - Vitamin D

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