Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon

Shagufta Shaheen, Achuta Kumar Guddati

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a rare entity. It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging. Colonoscopy may reveal lesions whose biopsy most commonly shows abundant B lymphocytes. There is no universal immunohistochemistry profile for MALT-type lymphoma but CD 20 staining is commonly seen. Trisomies and translocations have been described and their presence has been correlated with treatment response. Due to the rarity of colonic MALT-type lymphoma, no standard guidelines are available for its management. It often occurs individually and rarely occurs simultaneously with concurrent colon adenocarcinoma. This case report describes the presentation and clinical course of a secondary MALT-type lymphoma in a patient who underwent colectomy for a prior colon adenocarcinoma.

Original languageEnglish (US)
Article number502
JournalMedical Oncology
Volume30
Issue number2
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

Fingerprint

Marginal Zone B-Cell Lymphoma
Colon
Adenocarcinoma
Melena
Gastrointestinal Hemorrhage
Colectomy
Trisomy
Helicobacter Infections
Constipation
Colonoscopy
Helicobacter pylori
Weight Loss
Stomach
B-Lymphocytes
Fever
Immunohistochemistry
Guidelines
Staining and Labeling
Biopsy

Keywords

  • Adenocarcinoma
  • Colon
  • Lymphoma
  • MALT
  • Secondary

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon. / Shaheen, Shagufta; Guddati, Achuta Kumar.

In: Medical Oncology, Vol. 30, No. 2, 502, 01.06.2013.

Research output: Contribution to journalArticle

@article{099aa7b0c5bb48788b4dca9ce958b146,
title = "Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon",
abstract = "Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a rare entity. It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging. Colonoscopy may reveal lesions whose biopsy most commonly shows abundant B lymphocytes. There is no universal immunohistochemistry profile for MALT-type lymphoma but CD 20 staining is commonly seen. Trisomies and translocations have been described and their presence has been correlated with treatment response. Due to the rarity of colonic MALT-type lymphoma, no standard guidelines are available for its management. It often occurs individually and rarely occurs simultaneously with concurrent colon adenocarcinoma. This case report describes the presentation and clinical course of a secondary MALT-type lymphoma in a patient who underwent colectomy for a prior colon adenocarcinoma.",
keywords = "Adenocarcinoma, Colon, Lymphoma, MALT, Secondary",
author = "Shagufta Shaheen and Guddati, {Achuta Kumar}",
year = "2013",
month = "6",
day = "1",
doi = "10.1007/s12032-013-0502-2",
language = "English (US)",
volume = "30",
journal = "Medical Oncology",
issn = "1357-0560",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon

AU - Shaheen, Shagufta

AU - Guddati, Achuta Kumar

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a rare entity. It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging. Colonoscopy may reveal lesions whose biopsy most commonly shows abundant B lymphocytes. There is no universal immunohistochemistry profile for MALT-type lymphoma but CD 20 staining is commonly seen. Trisomies and translocations have been described and their presence has been correlated with treatment response. Due to the rarity of colonic MALT-type lymphoma, no standard guidelines are available for its management. It often occurs individually and rarely occurs simultaneously with concurrent colon adenocarcinoma. This case report describes the presentation and clinical course of a secondary MALT-type lymphoma in a patient who underwent colectomy for a prior colon adenocarcinoma.

AB - Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a rare entity. It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging. Colonoscopy may reveal lesions whose biopsy most commonly shows abundant B lymphocytes. There is no universal immunohistochemistry profile for MALT-type lymphoma but CD 20 staining is commonly seen. Trisomies and translocations have been described and their presence has been correlated with treatment response. Due to the rarity of colonic MALT-type lymphoma, no standard guidelines are available for its management. It often occurs individually and rarely occurs simultaneously with concurrent colon adenocarcinoma. This case report describes the presentation and clinical course of a secondary MALT-type lymphoma in a patient who underwent colectomy for a prior colon adenocarcinoma.

KW - Adenocarcinoma

KW - Colon

KW - Lymphoma

KW - MALT

KW - Secondary

UR - http://www.scopus.com/inward/record.url?scp=84873939802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873939802&partnerID=8YFLogxK

U2 - 10.1007/s12032-013-0502-2

DO - 10.1007/s12032-013-0502-2

M3 - Article

C2 - 23423787

AN - SCOPUS:84873939802

VL - 30

JO - Medical Oncology

JF - Medical Oncology

SN - 1357-0560

IS - 2

M1 - 502

ER -