Secretory proteins of the lung in rodents: Immunocytochemistry

G. Singh, S. L. Katyal, J. M. Ward, S. A. Gottron, M. L. Wong-Chong, E. J. Riley

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The reactivity of rabbit antisera to rat lung secretory proteins with other rodent species was evaluated by immunocytochemistry. Rabbit anti-rat surfactant apoprotein antiserum reacts with the cytoplasm of rat, mouse, and hamster type II pneumocytes and is specific for these cells. Rabbit antiserum to rat Clara cell secretory proteins stains rat, mouse, and hamster Clara cells. Rabbit antisera specific to the two antigenic types of rat Clara cell antigens were also both reactive with rat, mouse, and hamster Clara cells. An antiserum to the non-serum protein of hamster lung lavage was also prepared and showed to be specifically reactive with hamster Clara cells. The availability of specific reagents for secretory proteins of rodent lungs is expected to facilitate studies of the respective cell types in various pathologic states.

Original languageEnglish (US)
Pages (from-to)564-658
Number of pages95
JournalJournal of Histochemistry and Cytochemistry
Issue number6
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Histology


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