Background: Nox1, an oxidant source in colon carcinoma and vascular disease, is activated by NOXA1. Results: A NOXA1 peptide blocked NOXA1-Nox1 binding and inhibited colon carcinoma and endothelial oxidants and migration. Conclusion: The findings identify a NOXA1-Activating domain and an isoform-specific Nox1 inhibitor. Significance: The data provide insight into Nox1 regulation and present a potential therapy for suppressing oxidative stressrelated disease.
|Original language||English (US)|
|Number of pages||14|
|Journal||Journal of Biological Chemistry|
|State||Published - Dec 20 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology