Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

Tauheed Ishrat, Kehkashan Parveen, Mohd Moshahid Khan, Gulrana Khuwaja, Mohammad Badruzzaman Khan, Seema Yousuf, Ajmal Ahmad, Pallavi Shrivastav, Fakhrul Islam

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Selenium (Se), a nutritionally essential trace element with known antioxidant potential, protects the brain from oxidative damage in various models of neurodegeneration. Intracerebroventricular-streptozotocin (ICV-STZ) in rats causes impairment of brain glucose and energy metabolism along with oxidative damage and cholinergic dysfunction, and provides a relevant model for sporadic dementia of Alzheimer's type (SDAT). The present study demonstrates the therapeutic efficacy of Se on cognitive deficits and oxidative damage in ICV-STZ in rats. Male Wistar rats were pre-treated with sodium selenite, a salt of Se (0.1 mg/kg; body weight) for 7 days and then were injected bilaterally with ICV-STZ (3 mg/kg), while sham rats received the same volume of vehicle. After two ICV-STZ infusions, rats were tested for memory deficits in passive avoidance and Morris water maze (MWM) tests and then were sacrificed for biochemical and histopatholgical assays. ICV-STZ-infused rats showed significant loss in learning and memory ability, which were significantly improved by Se supplementation. A significant increase in thio-barbituric acid reactive species (TBARS), protein carbonyl (PC) and a significant decrease in reduced glutathione (GSH), antioxidant enzymes (glutathione peroxidase [GPx] and glutathione reductase [GR]) and adenosine triphosphate (ATP) in the hippocampus and cerebral cortex and choline acetyltransferase (ChAT) in hippocampus were observed in ICV-STZ rats. Se supplementation significantly ameliorated all alterations induced by ICV-STZ in rats. Our study reveals that Se, as a powerful antioxidant, prevents cognitive deficits, oxidative damage and morphological changes in the ICV-STZ rats. Thus, it may have a therapeutic value for the treatment of SDAT.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalBrain Research
Volume1281
DOIs
StatePublished - Jul 24 2009
Externally publishedYes

Fingerprint

Streptozocin
Selenium
Alzheimer Disease
Antioxidants
Hippocampus
Intraventricular Infusions
Sodium Selenite
Aptitude
Choline O-Acetyltransferase
Cognitive Dysfunction
Glutathione Reductase
Memory Disorders
Brain
Trace Elements
Glutathione Peroxidase
Cerebral Cortex
Cholinergic Agents
Energy Metabolism
Glutathione
Wistar Rats

Keywords

  • Adenosine triphosphate
  • Choline acetyltransferase
  • Cognitive deficits
  • Oxidative damage
  • Sodium selenite
  • Sporadic dementia of Alzheimer's type
  • Streptozotocin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. / Ishrat, Tauheed; Parveen, Kehkashan; Khan, Mohd Moshahid; Khuwaja, Gulrana; Khan, Mohammad Badruzzaman; Yousuf, Seema; Ahmad, Ajmal; Shrivastav, Pallavi; Islam, Fakhrul.

In: Brain Research, Vol. 1281, 24.07.2009, p. 117-127.

Research output: Contribution to journalArticle

Ishrat, Tauheed ; Parveen, Kehkashan ; Khan, Mohd Moshahid ; Khuwaja, Gulrana ; Khan, Mohammad Badruzzaman ; Yousuf, Seema ; Ahmad, Ajmal ; Shrivastav, Pallavi ; Islam, Fakhrul. / Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. In: Brain Research. 2009 ; Vol. 1281. pp. 117-127.
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AU - Khan, Mohammad Badruzzaman

AU - Yousuf, Seema

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