TY - JOUR
T1 - Self-reported quality of life in children with ventricular assist devices
AU - Peng, David M.
AU - Yu, Sunkyung
AU - Lowery, Ray
AU - Ventresco, Courtney
AU - Cousino, Melissa K
AU - St. Louis, James D.
AU - Blume, Elizabeth D.
AU - Uzark, Karen
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/6
Y1 - 2022/6
N2 - Background: We sought to describe QOL in children with VAD and to identify factors associated with impaired QOL. Methods: There were 82 children (6–19 years) in the Pediatric Interagency Registry for Mechanical Circulatory Support who completed the PedsQL +/− a VAD-specific QOL assessment pre-VAD implant (n = 18), 3 months post-VAD (n = 63), and/or 6 months post-VAD (n = 38). Significantly impaired QOL is a score >1 SD below norms. Results: Study patients were 59% male, 67% Caucasian, with cardiomyopathy diagnosis in 82%, and median age at implant of 14 y (IQR 11–17). PedsQL scores were lower than norms for physical (p <.0001) and psychosocial (p <.01) QOL in pre- and post-VAD groups. Compared to chronic health condition and complex or severe heart disease groups, PedsQL scores were lower for physical and psychosocial QOL in the pre-VAD group (p <.0001); however, psychosocial QOL was not significantly different in post-VAD groups. Psychosocial QOL was impaired in 67%, 40%, and 24% in pre-VAD, 3-month, and 6-month post-VAD groups, respectively. Total and psychosocial QOL scores were significantly higher in the 3-month and 6-month post-VAD group than pre-VAD (all p ≤.02). VAD patients were most bothered by their inability to participate in usual play activities. Impaired QOL 3 months post-VAD was associated with inotropic support >2 weeks/ongoing post-VAD (p =.04). Conclusion: Physical QOL is significantly impaired in most children pre- and post-VAD. However, psychosocial QOL is not significantly impaired in most children post-VAD suggesting VAD implantation may improve psychosocial QOL in children.
AB - Background: We sought to describe QOL in children with VAD and to identify factors associated with impaired QOL. Methods: There were 82 children (6–19 years) in the Pediatric Interagency Registry for Mechanical Circulatory Support who completed the PedsQL +/− a VAD-specific QOL assessment pre-VAD implant (n = 18), 3 months post-VAD (n = 63), and/or 6 months post-VAD (n = 38). Significantly impaired QOL is a score >1 SD below norms. Results: Study patients were 59% male, 67% Caucasian, with cardiomyopathy diagnosis in 82%, and median age at implant of 14 y (IQR 11–17). PedsQL scores were lower than norms for physical (p <.0001) and psychosocial (p <.01) QOL in pre- and post-VAD groups. Compared to chronic health condition and complex or severe heart disease groups, PedsQL scores were lower for physical and psychosocial QOL in the pre-VAD group (p <.0001); however, psychosocial QOL was not significantly different in post-VAD groups. Psychosocial QOL was impaired in 67%, 40%, and 24% in pre-VAD, 3-month, and 6-month post-VAD groups, respectively. Total and psychosocial QOL scores were significantly higher in the 3-month and 6-month post-VAD group than pre-VAD (all p ≤.02). VAD patients were most bothered by their inability to participate in usual play activities. Impaired QOL 3 months post-VAD was associated with inotropic support >2 weeks/ongoing post-VAD (p =.04). Conclusion: Physical QOL is significantly impaired in most children pre- and post-VAD. However, psychosocial QOL is not significantly impaired in most children post-VAD suggesting VAD implantation may improve psychosocial QOL in children.
UR - http://www.scopus.com/inward/record.url?scp=85123932702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123932702&partnerID=8YFLogxK
U2 - 10.1111/petr.14237
DO - 10.1111/petr.14237
M3 - Article
C2 - 35102660
AN - SCOPUS:85123932702
SN - 1397-3142
VL - 26
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 4
M1 - e14237
ER -