Seprafilm® adhesion barrier: (1) A review of preclinical, animal, and human investigational studies

Michael P. Diamond, Ellen L. Burns, Beverly Accomando, Sadiqa Mian, Lena Holmdahl

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

The aim of this study was to provide a single site resource for investigators, clinicians, and others seeking preclinical, animal, and human investigational studies concerning the postsurgical, anti-adhesion barrier Seprafilm ™(Genzyme Corporation, Cambridge, MA). All published preclinical, animal, human extra-abdominal research as of July 2011 have been summarized and included in this document. Searches of Medline and EMBASE Drugs and Pharmaceuticals databases were conducted for original preclinical, animal, and human extra-abdominal studies involving Seprafilm. Preclinical, animal, and extra-abdominal human investigational studies are the study selection for this manuscript. Intraabdominal use is discussed in the accompanying manuscript. Data extraction includes systematic manuscript review. Summary of preclinical, animal, and extra-abdominal human investigational use of Seprafilm by surgical discipline were gathered for data synthesis. The clinical use of Seprafilm, which was approved by the FDA for intra-abdominal procedures, is supported by preclinical and animal studies relating to general surgical and obstetrical/ gynecological applications. Findings from preclinical, animal, and human investigational studies at other sites throughout the body raises the potential for additional human clinical trials to assess efficacy and safety following surgical procedures at non-abdominal locations.

Original languageEnglish (US)
Pages (from-to)237-245
Number of pages9
JournalGynecological Surgery
Volume9
Issue number3
DOIs
StatePublished - Sep 2012

Keywords

  • Adhesiolysis
  • Anti-adhesion adjuvant
  • Postoperative adhesions
  • Seprafilm

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

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