Serum protein mediators of dementia and aging proper

Donald R. Royall, Safa Al-Rubaye, Ram Bishnoi, Raymond F. Palmer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The latent variable "δ" (for "dementia") appears to be uniquely responsible for the dementing aspects of cognitive impairment. Age, depressive symptoms, gender and the apolipoprotein E (APOE) ε4 allele are independently associated with δ. In this analysis, we explore serum proteins as potential mediators of age's specific association with δ in a large, ethnically diverse longitudinal cohort, the Texas Alzheimer's Research and Care Consortium (TARCC). 22 serum proteins were recognized as partial mediators of age's association with δ. These include Insulin-like Growth Factor-Binding Protein 2 (IGF-BP2), which we had previously associated with age-specific cognitive change, and both Pancreatic Polypeptide (PP) and von Willebrand Factor (vWF), previously associated with δ. Nine other δ-related proteins were not confirmed by this ethnicity adjusted analysis. Our findings suggest that age's association with the disabling fraction of cognitive performance is partially mediated by serum proteins, somatomedins and hormones. Those proteins may offer targets for the specific treatment of age-related effects on dementia severity and conversion risk.

Original languageEnglish (US)
Pages (from-to)3241-3254
Number of pages14
JournalAging
Volume8
Issue number12
DOIs
StatePublished - Jan 1 2016

Keywords

  • Aging
  • Cognition
  • Dementia
  • Functional status
  • G
  • Intelligence

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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    Royall, D. R., Al-Rubaye, S., Bishnoi, R., & Palmer, R. F. (2016). Serum protein mediators of dementia and aging proper. Aging, 8(12), 3241-3254. https://doi.org/10.18632/aging.101091