Serum sodium stabilizing effect of enalapril after standard water load in a patient with a history of self-induced water intoxication

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Abstract

1. 1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. 4. After a water load, the mean serum sodium on enalpril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.

Original languageEnglish (US)
Pages (from-to)655-663
Number of pages9
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume19
Issue number4
DOIs
StatePublished - Jan 1 1995

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Water Intoxication
Enalapril
Sodium
Placebos
Water
Serum
Cross-Over Studies
Therapeutics

Keywords

  • angiotensin
  • enalapril
  • hyponatremia
  • psychogenicpolydipsia
  • self-induced water intoxication

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

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title = "Serum sodium stabilizing effect of enalapril after standard water load in a patient with a history of self-induced water intoxication",
abstract = "1. 1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. 4. After a water load, the mean serum sodium on enalpril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.",
keywords = "angiotensin, enalapril, hyponatremia, psychogenicpolydipsia, self-induced water intoxication",
author = "Sebastian, {C Simon} and Dharmbeer Sinha and Gulati, {Nidhi K}",
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T1 - Serum sodium stabilizing effect of enalapril after standard water load in a patient with a history of self-induced water intoxication

AU - Sebastian, C Simon

AU - Sinha, Dharmbeer

AU - Gulati, Nidhi K

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N2 - 1. 1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. 4. After a water load, the mean serum sodium on enalpril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.

AB - 1. 1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. 4. After a water load, the mean serum sodium on enalpril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.

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KW - enalapril

KW - hyponatremia

KW - psychogenicpolydipsia

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