1. 1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. 4. After a water load, the mean serum sodium on enalpril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.
|Original language||English (US)|
|Number of pages||9|
|Journal||Progress in Neuropsychopharmacology and Biological Psychiatry|
|State||Published - Jan 1 1995|
- self-induced water intoxication
ASJC Scopus subject areas
- Biological Psychiatry