Severe and Progressive Cellulitis Caused by Serratia marcescens Following a Dog Scratch

Deeti J. Pithadia, Erena N. Weathers, Rhonda E. Colombo, Stephanie L. Baer

Research output: Contribution to journalArticle

Abstract

Soft tissue infections occur in over 30% of patients with chemotherapy-induced neutropenia. Gram-positive bacterial infections predominate early in neutropenia, and likelihood of infection by resistant bacteria and fungi increases with prolonged neutropenia. Prior infections and exposures influence the risk of rare pathogens. A 55-year-old woman with chemotherapy-induced neutropenia was scratched on her forearm by a dog. She cleaned the wound with isopropanol and was treated empirically with amoxicillin-clavulanate. Over the next 4 days, she developed fever along with erythema, edema, and mild tenderness of the forearm without purulence or crepitus. She was hospitalized and received empiric treatment with intravenous vancomycin, piperacillin-tazobactam, tobramycin, and voriconazole. Despite therapy, her fevers persisted and the cellulitis progressed for over a week. After 10 days of hospitalization, her neutrophil count began to recover and a bulla developed at the wound site. Culture of the bullous fluid grew Serratia marcescens, and antibiotics were switched to cefepime based on susceptibility. She defervesced and showed substantial improvement of cellulitis within 48 hours and was discharged on oral ciprofloxacin. Serratia marcescens skin infections are rare, and this may be the first report of Serratia cellulitis associated with trauma from dog contact. This case highlights the need to consider unusual pathogens based on exposure history and immune status and to obtain cultures from fluid collections or tissue in cases of treatment-resistant soft tissue infections.

Original languageEnglish (US)
JournalJournal of Investigative Medicine High Impact Case Reports
Volume7
DOIs
StatePublished - Feb 1 2019

Fingerprint

Serratia marcescens
Cellulitis
Neutropenia
Chemotherapy
Pathogens
Dogs
Tissue
empirics
Soft Tissue Infections
hospitalization
Forearm
trauma
Gram-Positive Bacterial Infections
Wounds and Injuries
Fever
Fluids
Infection
contact
Antibiotics
Fungi

Keywords

  • Serratia marcescens
  • cellulitis
  • dog scratch
  • immunocompromised
  • skin infection

ASJC Scopus subject areas

  • Epidemiology
  • Safety, Risk, Reliability and Quality
  • Safety Research

Cite this

Severe and Progressive Cellulitis Caused by Serratia marcescens Following a Dog Scratch. / Pithadia, Deeti J.; Weathers, Erena N.; Colombo, Rhonda E.; Baer, Stephanie L.

In: Journal of Investigative Medicine High Impact Case Reports, Vol. 7, 01.02.2019.

Research output: Contribution to journalArticle

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