Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Jeffrey C. Hageman, Timothy M. Uyeki, John S Francis, Daniel B. Jernigan, J. Gary Wheeler, Carolyn B. Bridges, Stephen J. Barenkamp, Dawn M. Sievert, Arjun Srinivasan, Meg C. Doherty, Linda K. McDougal, George E. Killgore, Uri A. Lopatin, Rebecca Coffman, J. Kathryn MacDonald, Sigrid K. McAllister, Gregory E. Fosheim, Jean B. Patel, L. Clifford McDonald

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

Original languageEnglish (US)
Pages (from-to)894-899
Number of pages6
JournalEmerging Infectious Diseases
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Methicillin-Resistant Staphylococcus aureus
Human Influenza
Staphylococcus aureus
Pneumonia
Pulsed Field Gel Electrophoresis
Virus Diseases
Orthomyxoviridae
Genes
Chromosomes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Hageman, J. C., Uyeki, T. M., Francis, J. S., Jernigan, D. B., Wheeler, J. G., Bridges, C. B., ... McDonald, L. C. (2006). Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. Emerging Infectious Diseases, 12(6), 894-899. https://doi.org/10.3201/eid1206.051141

Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. / Hageman, Jeffrey C.; Uyeki, Timothy M.; Francis, John S; Jernigan, Daniel B.; Wheeler, J. Gary; Bridges, Carolyn B.; Barenkamp, Stephen J.; Sievert, Dawn M.; Srinivasan, Arjun; Doherty, Meg C.; McDougal, Linda K.; Killgore, George E.; Lopatin, Uri A.; Coffman, Rebecca; MacDonald, J. Kathryn; McAllister, Sigrid K.; Fosheim, Gregory E.; Patel, Jean B.; McDonald, L. Clifford.

In: Emerging Infectious Diseases, Vol. 12, No. 6, 01.01.2006, p. 894-899.

Research output: Contribution to journalArticle

Hageman, JC, Uyeki, TM, Francis, JS, Jernigan, DB, Wheeler, JG, Bridges, CB, Barenkamp, SJ, Sievert, DM, Srinivasan, A, Doherty, MC, McDougal, LK, Killgore, GE, Lopatin, UA, Coffman, R, MacDonald, JK, McAllister, SK, Fosheim, GE, Patel, JB & McDonald, LC 2006, 'Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season', Emerging Infectious Diseases, vol. 12, no. 6, pp. 894-899. https://doi.org/10.3201/eid1206.051141
Hageman, Jeffrey C. ; Uyeki, Timothy M. ; Francis, John S ; Jernigan, Daniel B. ; Wheeler, J. Gary ; Bridges, Carolyn B. ; Barenkamp, Stephen J. ; Sievert, Dawn M. ; Srinivasan, Arjun ; Doherty, Meg C. ; McDougal, Linda K. ; Killgore, George E. ; Lopatin, Uri A. ; Coffman, Rebecca ; MacDonald, J. Kathryn ; McAllister, Sigrid K. ; Fosheim, Gregory E. ; Patel, Jean B. ; McDonald, L. Clifford. / Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. In: Emerging Infectious Diseases. 2006 ; Vol. 12, No. 6. pp. 894-899.
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